BRD-U37049823_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-U37049823_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
AKR1C3 aldo-keto reductase family 1, member C3
AQP1 aquaporin 1 (Colton blood group)
BTG2 BTG family, member 2
CCL5 chemokine (C-C motif) ligand 5
COL4A1 collagen, type IV, alpha 1
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM117A family with sequence similarity 117, member A
FAM129A family with sequence similarity 129, member A
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HOXA5 homeobox A5
IFITM1 interferon induced transmembrane protein 1
KRT6A keratin 6A, type II
LITAF lipopolysaccharide-induced TNF factor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1C1 mannosidase, alpha, class 1C, member 1
NCOA2 nuclear receptor coactivator 2
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PDZK1IP1 PDZK1 interacting protein 1
POSTN periostin, osteoblast specific factor
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RUNX3 runt-related transcription factor 3
SIK1 salt-inducible kinase 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPARCL1 SPARC-like 1 (hevin)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
AOX1 aldehyde oxidase 1
APOA2 apolipoprotein A-II
APOH apolipoprotein H (beta-2-glycoprotein I)
ARHGAP29 Rho GTPase activating protein 29
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASPH aspartate beta-hydroxylase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BZW1 basic leucine zipper and W2 domains 1
CALU calumenin
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCND1 cyclin D1
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CRYZ crystallin, zeta (quinone reductase)
CTGF connective tissue growth factor
CTSB cathepsin B
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
FKBP1A FK506 binding protein 1A, 12kDa
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GBE1 glucan (1,4-alpha-), branching enzyme 1
GDI2 GDP dissociation inhibitor 2
GLRX glutaredoxin (thioltransferase)
GLRX3 glutaredoxin 3
GOLT1B golgi transport 1B
HAT1 histone acetyltransferase 1
HSPA8 heat shock 70kDa protein 8
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IER3 immediate early response 3
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT18 keratin 18, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKSL1 MARCKS-like 1
MMD monocyte to macrophage differentiation-associated
NT5E 5'-nucleotidase, ecto (CD73)
PAM peptidylglycine alpha-amidating monooxygenase
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
PNP purine nucleoside phosphorylase
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PXDN peroxidasin
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
RPS11 ribosomal protein S11
SEC23A Sec23 homolog A (S. cerevisiae)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOX4 SRY (sex determining region Y)-box 4
SRPX2 sushi-repeat containing protein, X-linked 2
SSR1 signal sequence receptor, alpha
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TUBB tubulin, beta class I
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VCAN versican
WSB2 WD repeat and SOCS box containing 2
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta