BRD-U33728988_-666_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-U33728988_-666_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
BIK BCL2-interacting killer (apoptosis-inducing)
BRD2 bromodomain containing 2
CD24 CD24 molecule
CDK19 cyclin-dependent kinase 19
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPP4 dipeptidyl-peptidase 4
EFNA1 ephrin-A1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM69A family with sequence similarity 69, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GLS glutaminase
GOLGA8A golgin A8 family, member A
GRAMD3 GRAM domain containing 3
GRWD1 glutamate-rich WD repeat containing 1
HBP1 HMG-box transcription factor 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
INHBB inhibin, beta B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
LOX lysyl oxidase
LTF lactotransferrin
MFAP5 microfibrillar associated protein 5
MYL1 myosin, light chain 1, alkali; skeletal, fast
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2B olfactomedin-like 2B
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE4DIP phosphodiesterase 4D interacting protein
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
PLXNC1 plexin C1
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
QKI QKI, KH domain containing, RNA binding
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC14L1 SEC14-like 1 (S. cerevisiae)
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNNC2 troponin C type 2 (fast)
TNNT1 troponin T type 1 (skeletal, slow)
TXNL4B thioredoxin-like 4B
ZBTB20 zinc finger and BTB domain containing 20
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AEBP1 AE binding protein 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKMY2 ankyrin repeat and MYND domain containing 2
AQP3 aquaporin 3 (Gill blood group)
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BZW2 basic leucine zipper and W2 domains 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CLGN calmegin
COL4A5 collagen, type IV, alpha 5
COL6A2 collagen, type VI, alpha 2
COPS7A COP9 signalosome subunit 7A
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5A eukaryotic translation initiation factor 5A
ENOPH1 enolase-phosphatase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
GAL galanin/GMAP prepropeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPRASP1 G protein-coupled receptor associated sorting protein 1
HBB hemoglobin, beta
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA1A heat shock 70kDa protein 1A
HTRA1 HtrA serine peptidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2A integral membrane protein 2A
KANK2 KN motif and ankyrin repeat domains 2
KCTD12 potassium channel tetramerization domain containing 12
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LEF1 lymphoid enhancer-binding factor 1
LMO2 LIM domain only 2 (rhombotin-like 1)
M6PR mannose-6-phosphate receptor (cation dependent)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUDCD3 NudC domain containing 3
PCTP phosphatidylcholine transfer protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLBD1 phospholipase B domain containing 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCI protein kinase C, iota
PRSS3 protease, serine, 3
RGS2 regulator of G-protein signaling 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SGK1 serum/glucocorticoid regulated kinase 1
SLC35E3 solute carrier family 35, member E3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
TM9SF2 transmembrane 9 superfamily member 2
TMEM109 transmembrane protein 109
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8