BRD-U07805514_saracatinib_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-U07805514_saracatinib_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
BST2 bone marrow stromal cell antigen 2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CTSB cathepsin B
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFB1 defensin, beta 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EMP3 epithelial membrane protein 3
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
FN1 fibronectin 1
GDF15 growth differentiation factor 15
GLIPR1 GLI pathogenesis-related 1
H3F3B H3 histone, family 3B (H3.3B)
HIRA histone cell cycle regulator
HK1 hexokinase 1
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
JUN jun proto-oncogene
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LCN2 lipocalin 2
LMNA lamin A/C
LPL lipoprotein lipase
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MMP9 matrix metallopeptidase 9
MT1H metallothionein 1H
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
PCYOX1 prenylcysteine oxidase 1
PDGFC platelet derived growth factor C
PDLIM4 PDZ and LIM domain 4
PERP PERP, TP53 apoptosis effector
PPAP2B phosphatidic acid phosphatase type 2B
PRNP prion protein
PRR7 proline rich 7 (synaptic)
SFN stratifin
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AURKB aurora kinase B
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCL4 chemokine (C-C motif) ligand 4
COL5A2 collagen, type V, alpha 2
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DKK1 dickkopf WNT signaling pathway inhibitor 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALE UDP-galactose-4-epimerase
GATA6 GATA binding protein 6
GIMAP5 GTPase, IMAP family member 5
GRK5 G protein-coupled receptor kinase 5
GSTA1 glutathione S-transferase alpha 1
GYPC glycophorin C (Gerbich blood group)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HDAC6 histone deacetylase 6
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP5 insulin-like growth factor binding protein 5
KRT18 keratin 18, type I
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MB myoglobin
MEA1 male-enhanced antigen 1
MRPL57 mitochondrial ribosomal protein L57
MYRF myelin regulatory factor
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NRN1 neuritin 1
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG3 paternally expressed 3
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLN phospholamban
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R13B protein phosphatase 1, regulatory subunit 13B
ROGDI rogdi homolog (Drosophila)
RPA3 replication protein A3, 14kDa
RPS11 ribosomal protein S11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TCEAL4 transcription elongation factor A (SII)-like 4
TCTA T-cell leukemia translocation altered
TES testin LIM domain protein
THTPA thiamine triphosphatase
TPSAB1 tryptase alpha/beta 1
TSPAN8 tetraspanin 8
UXT ubiquitously-expressed, prefoldin-like chaperone
WBP5 WW domain binding protein 5