BRD-U07805514_saracatinib_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-U07805514_saracatinib_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT9 acyl-CoA thioesterase 9
AK4 adenylate kinase 4
AKAP13 A kinase (PRKA) anchor protein 13
ALDOC aldolase C, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALML5 calmodulin-like 5
CAV1 caveolin 1, caveolae protein, 22kDa
COASY CoA synthase
COL6A1 collagen, type VI, alpha 1
CTSB cathepsin B
CTSL cathepsin L
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DEGS1 delta(4)-desaturase, sphingolipid 1
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
ENO2 enolase 2 (gamma, neuronal)
FAM162A family with sequence similarity 162, member A
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
HK2 hexokinase 2
HOXA5 homeobox A5
HSPA13 heat shock protein 70kDa family, member 13
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
KLF6 Kruppel-like factor 6
LMNA lamin A/C
LMO3 LIM domain only 3 (rhombotin-like 2)
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MAGEA4 melanoma antigen family A4
MAGEA6 melanoma antigen family A6
MCOLN1 mucolipin 1
MCTP1 multiple C2 domains, transmembrane 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPC1 Niemann-Pick disease, type C1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP1 plakophilin 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLTP phospholipid transfer protein
PRNP prion protein
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
SASH1 SAM and SH3 domain containing 1
SDC4 syndecan 4
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SFN stratifin
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLURP1 secreted LY6/PLAUR domain containing 1
SNX2 sorting nexin 2
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
STEAP1 six transmembrane epithelial antigen of the prostate 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ASRGL1 asparaginase like 1
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BID BH3 interacting domain death agonist
BMP4 bone morphogenetic protein 4
C8ORF4 chromosome 8 open reading frame 4
CCND3 cyclin D3
CD24 CD24 molecule
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CFB complement factor B
CHMP4A charged multivesicular body protein 4A
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DHFR dihydrofolate reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHF ets homologous factor
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GINS1 GINS complex subunit 1 (Psf1 homolog)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS1 insulin receptor substrate 1
KRT7 keratin 7, type II
LRP10 low density lipoprotein receptor-related protein 10
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MATN2 matrilin 2
MEA1 male-enhanced antigen 1
MGP matrix Gla protein
MRPL12 mitochondrial ribosomal protein L12
MRPS16 mitochondrial ribosomal protein S16
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NIPSNAP1 nipsnap homolog 1 (C. elegans)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDE4B phosphodiesterase 4B, cAMP-specific
PLBD1 phospholipase B domain containing 1
PSD3 pleckstrin and Sec7 domain containing 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PYCARD PYD and CARD domain containing
S100A9 S100 calcium binding protein A9
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMC4 structural maintenance of chromosomes 4
SPTSSA serine palmitoyltransferase, small subunit A
SRSF7 serine/arginine-rich splicing factor 7
TBC1D4 TBC1 domain family, member 4
TFPI2 tissue factor pathway inhibitor 2
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
TPM1 tropomyosin 1 (alpha)
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP1 ubiquitin specific peptidase 1
XBP1 X-box binding protein 1