BRD-M86331534_BJM-ctd2-9_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

403 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AHR aryl hydrocarbon receptor
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL3 B-cell CLL/lymphoma 3
BGN biglycan
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C3ORF14 chromosome 3 open reading frame 14
C8ORF4 chromosome 8 open reading frame 4
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLEC3B C-type lectin domain family 3, member B
CNN3 calponin 3, acidic
COLEC12 collectin sub-family member 12
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRNP2 cysteine-serine-rich nuclear protein 2
CTH cystathionine gamma-lyase
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYB5R2 cytochrome b5 reductase 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSC2 desmocollin 2
DTNA dystrobrevin, alpha
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP3 dual specificity phosphatase 3
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
FAM129A family with sequence similarity 129, member A
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FILIP1L filamin A interacting protein 1-like
FLOT1 flotillin 1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
IL32 interleukin 32
INHBA inhibin, beta A
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA0040 KIAA0040
KIAA0226L KIAA0226-like
KIAA0907 KIAA0907
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
LARP6 La ribonucleoprotein domain family, member 6
LDOC1 leucine zipper, down-regulated in cancer 1
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MEX3C mex-3 RNA binding family member C
MGP matrix Gla protein
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
MYO6 myosin VI
NAMPT nicotinamide phosphoribosyltransferase
NARS asparaginyl-tRNA synthetase
NBPF10 neuroblastoma breakpoint family, member 10
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NNMT nicotinamide N-methyltransferase
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
OSBPL1A oxysterol binding protein-like 1A
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PER1 period circadian clock 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTPRE protein tyrosine phosphatase, receptor type, E
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCAN1 regulator of calcineurin 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RHOB ras homolog family member B
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
RYBP RING1 and YY1 binding protein
SARS seryl-tRNA synthetase
SCG2 secretogranin II
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SECISBP2L SECIS binding protein 2-like
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPB surfactant protein B
SGCE sarcoglycan, epsilon
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SST somatostatin
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
TARS threonyl-tRNA synthetase
TGFBI transforming growth factor, beta-induced, 68kDa
TICAM1 toll-like receptor adaptor molecule 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TMEM100 transmembrane protein 100
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM2 transmembrane protein 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
WARS tryptophanyl-tRNA synthetase
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3
ZFP36 ZFP36 ring finger protein
ZNF24 zinc finger protein 24

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
AURKA aurora kinase A
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CAPN3 calpain 3, (p94)
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFI complement factor I
CHEK2 checkpoint kinase 2
CLU clusterin
COL4A6 collagen, type IV, alpha 6
CSNK1E casein kinase 1, epsilon
CST7 cystatin F (leukocystatin)
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EMX2 empty spiracles homeobox 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXM1 forkhead box M1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GEMIN4 gem (nuclear organelle) associated protein 4
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPNMB glycoprotein (transmembrane) nmb
GREB1 growth regulation by estrogen in breast cancer 1
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB7 homeobox B7
IFI16 interferon, gamma-inducible protein 16
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ISG15 ISG15 ubiquitin-like modifier
KAZN kazrin, periplakin interacting protein
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MECOM MDS1 and EVI1 complex locus
MIS18A MIS18 kinetochore protein A
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MSLN mesothelin
MUC4 mucin 4, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NOP56 NOP56 ribonucleoprotein
NPTXR neuronal pentraxin receptor
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PI3 peptidase inhibitor 3, skin-derived
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRC1 protein regulator of cytokinesis 1
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRPF19 pre-mRNA processing factor 19
PSRC1 proline/serine-rich coiled-coil 1
PTDSS1 phosphatidylserine synthase 1
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
RCC1 regulator of chromosome condensation 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SAMM50 SAMM50 sorting and assembly machinery component
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SORD sorbitol dehydrogenase
SPAG5 sperm associated antigen 5
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDP1 tyrosyl-DNA phosphodiesterase 1
TMEM109 transmembrane protein 109
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTK TTK protein kinase
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VANGL1 VANGL planar cell polarity protein 1
VDAC3 voltage-dependent anion channel 3
VRK1 vaccinia related kinase 1
WT1 Wilms tumor 1
WWTR1 WW domain containing transcription regulator 1
ZNF185 zinc finger protein 185 (LIM domain)