BRD-M86331534_BJM-ctd2-9_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

249 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
ANKRD10 ankyrin repeat domain 10
AREG amphiregulin
ARG2 arginase 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL10 B-cell CLL/lymphoma 10
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CCNG2 cyclin G2
CCNL1 cyclin L1
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CNOT4 CCR4-NOT transcription complex, subunit 4
COL15A1 collagen, type XV, alpha 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EMP1 epithelial membrane protein 1
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GBP1 guanylate binding protein 1, interferon-inducible
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
GSPT2 G1 to S phase transition 2
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCCS holocytochrome c synthase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IFRD1 interferon-related developmental regulator 1
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
IRF1 interferon regulatory factor 1
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUP junction plakoglobin
KDM3A lysine (K)-specific demethylase 3A
KIAA0907 KIAA0907
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MMD monocyte to macrophage differentiation-associated
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PALLD palladin, cytoskeletal associated protein
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G16 phospholipase A2, group XVI
PLAGL1 pleiomorphic adenoma gene-like 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PRNP prion protein
PRSS23 protease, serine, 23
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTBP2 polypyrimidine tract binding protein 2
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB9A RAB9A, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RBM34 RNA binding motif protein 34
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
SRSF11 serine/arginine-rich splicing factor 11
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TF transferrin
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBB6 tubulin, beta 6 class V
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
USP15 ubiquitin specific peptidase 15
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator
XBP1 X-box binding protein 1
ZEB2 zinc finger E-box binding homeobox 2
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AEBP1 AE binding protein 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APMAP adipocyte plasma membrane associated protein
AURKB aurora kinase B
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BMP4 bone morphogenetic protein 4
BST2 bone marrow stromal cell antigen 2
CANX calnexin
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
COPA coatomer protein complex, subunit alpha
CRIP2 cysteine-rich protein 2
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
DCTPP1 dCTP pyrophosphatase 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ENO2 enolase 2 (gamma, neuronal)
FGFR4 fibroblast growth factor receptor 4
FKBP10 FK506 binding protein 10, 65 kDa
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGA2 high mobility group AT-hook 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIF20A kinesin family member 20A
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCUR1 mitochondrial calcium uniporter regulator 1
METRN meteorin, glial cell differentiation regulator
MLEC malectin
MRPL34 mitochondrial ribosomal protein L34
MRPS16 mitochondrial ribosomal protein S16
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOTCH3 notch 3
NR2F6 nuclear receptor subfamily 2, group F, member 6
NT5DC2 5'-nucleotidase domain containing 2
NUP62 nucleoporin 62kDa
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRPF6 pre-mRNA processing factor 6
PTDSS1 phosphatidylserine synthase 1
PURA purine-rich element binding protein A
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SIX1 SIX homeobox 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SOX4 SRY (sex determining region Y)-box 4
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
THAP11 THAP domain containing 11
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM97 transmembrane protein 97
UBE2C ubiquitin-conjugating enzyme E2C
WFS1 Wolfram syndrome 1 (wolframin)
WT1 Wilms tumor 1