BRD-M86331534_BJM-ctd2-9_SNUC4_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_SNUC4_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ANOS1 anosmin 1
APOC1 apolipoprotein C-I
AREG amphiregulin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
BTG2 BTG family, member 2
CAST calpastatin
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD9 CD9 molecule
CFB complement factor B
CHIC2 cysteine-rich hydrophobic domain 2
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EXT1 exostosin glycosyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GUSBP11 glucuronidase, beta pseudogene 11
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IL6 interleukin 6
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
LRRC16A leucine rich repeat containing 16A
MCL1 myeloid cell leukemia 1
MOK MOK protein kinase
MT1E metallothionein 1E
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRK protein tyrosine phosphatase, receptor type, K
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRPS1 trichorhinophalangeal syndrome I
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ATF5 activating transcription factor 5
B3GNT1
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CD59 CD59 molecule, complement regulatory protein
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTTN cortactin
FAM57A family with sequence similarity 57, member A
FAP fibroblast activation protein, alpha
FCGBP Fc fragment of IgG binding protein
FLG filaggrin
GOLGA8A golgin A8 family, member A
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
METRN meteorin, glial cell differentiation regulator
MMP11 matrix metallopeptidase 11
NRN1 neuritin 1
OLFML3 olfactomedin-like 3
PGAM1 phosphoglycerate mutase 1 (brain)
POU4F1 POU class 4 homeobox 1
PTGES prostaglandin E synthase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK5 serine peptidase inhibitor, Kazal type 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)