BRD-M86331534_BJM-ctd2-9_SKMEL28_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_SKMEL28_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AMIGO2 adhesion molecule with Ig-like domain 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOB apolipoprotein B
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
C3ORF14 chromosome 3 open reading frame 14
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL15A1 collagen, type XV, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DEGS1 delta(4)-desaturase, sphingolipid 1
DICER1 dicer 1, ribonuclease type III
DPYD dihydropyrimidine dehydrogenase
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESM1 endothelial cell-specific molecule 1
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KRT8 keratin 8, type II
LAPTM4B lysosomal protein transmembrane 4 beta
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYRF myelin regulatory factor
NCF2 neutrophil cytosolic factor 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PON3 paraoxonase 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RNF167 ring finger protein 167
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIK1 salt-inducible kinase 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX9 SRY (sex determining region Y)-box 9
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STX1A syntaxin 1A (brain)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TBX3 T-box 3
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AKAP12 A kinase (PRKA) anchor protein 12
APOD apolipoprotein D
BIN1 bridging integrator 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CCNG2 cyclin G2
CD58 CD58 molecule
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENDOD1 endonuclease domain containing 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
GMDS GDP-mannose 4,6-dehydratase
HOPX HOP homeobox
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHM immunoglobulin heavy constant mu
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
KDM5D lysine (K)-specific demethylase 5D
KIF14 kinesin family member 14
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MYB v-myb avian myeloblastosis viral oncogene homolog
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OXA1L oxidase (cytochrome c) assembly 1-like
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PRKCZ protein kinase C, zeta
PUF60 poly-U binding splicing factor 60KDa
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPIA ribose 5-phosphate isomerase A
S100B S100 calcium binding protein B
SAMM50 SAMM50 sorting and assembly machinery component
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORBS1 sorbin and SH3 domain containing 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TBC1D4 TBC1 domain family, member 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM47 transmembrane protein 47
USP6NL USP6 N-terminal like
ZBTB18 zinc finger and BTB domain containing 18
ZIC1 Zic family member 1