BRD-M86331534_BJM-ctd2-9_SKLU1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BLNK B-cell linker
BTG2 BTG family, member 2
C3 complement component 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HCP5 HLA complex P5 (non-protein coding)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KIAA0907 KIAA0907
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP9 matrix metallopeptidase 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
ORM1 orosomucoid 1
PDE4B phosphodiesterase 4B, cAMP-specific
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
RAP1GAP2 RAP1 GTPase activating protein 2
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SOD2 superoxide dismutase 2, mitochondrial
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TMEM176B transmembrane protein 176B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UBE2G1 ubiquitin-conjugating enzyme E2G 1
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ANXA6 annexin A6
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAD BCL2-associated agonist of cell death
C16ORF45 chromosome 16 open reading frame 45
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
COL5A1 collagen, type V, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
ECI2 enoyl-CoA delta isomerase 2
EMP3 epithelial membrane protein 3
ENO2 enolase 2 (gamma, neuronal)
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM57A family with sequence similarity 57, member A
FCGBP Fc fragment of IgG binding protein
FLRT2 fibronectin leucine rich transmembrane protein 2
FXYD5 FXYD domain containing ion transport regulator 5
GAS2L1 growth arrest-specific 2 like 1
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LAMP1 lysosomal-associated membrane protein 1
LMNB1 lamin B1
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPC2 Niemann-Pick disease, type C2
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
PFKP phosphofructokinase, platelet
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLS1 plastin 1
PNMA1 paraneoplastic Ma antigen 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRR7 proline rich 7 (synaptic)
PSPH phosphoserine phosphatase
PTDSS1 phosphatidylserine synthase 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHCBP1 SHC SH2-domain binding protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SPA17 sperm autoantigenic protein 17
SVIL supervillin
TACC3 transforming, acidic coiled-coil containing protein 3
THYN1 thymocyte nuclear protein 1
TOP2B topoisomerase (DNA) II beta 180kDa
TRAPPC3 trafficking protein particle complex 3
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTC3 tetratricopeptide repeat domain 3