BRD-M86331534_BJM-ctd2-9_RMUGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_RMUGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AKIRIN1 akirin 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
C3ORF52 chromosome 3 open reading frame 52
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
CNPY3 canopy FGF signaling regulator 3
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPY19L1 dpy-19-like 1 (C. elegans)
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EFNB2 ephrin-B2
EGR2 early growth response 2
EGR3 early growth response 3
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GLDC glycine dehydrogenase (decarboxylating)
GRAMD3 GRAM domain containing 3
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
ICAM1 intercellular adhesion molecule 1
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K3 mitogen-activated protein kinase kinase 3
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOSIP nitric oxide synthase interacting protein
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OAT ornithine aminotransferase
OXTR oxytocin receptor
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIH1D1 PIH1 domain containing 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RSL24D1 ribosomal L24 domain containing 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UGCG UDP-glucose ceramide glucosyltransferase
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNA2 cyclin A2
CD93 CD93 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLEC2B C-type lectin domain family 2, member B
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYTH1 cytohesin 1
DENND1B DENN/MADD domain containing 1B
DERA deoxyribose-phosphate aldolase (putative)
DPYSL3 dihydropyrimidinase-like 3
ECHDC3 enoyl CoA hydratase domain containing 3
FBN1 fibrillin 1
FN1 fibronectin 1
FXYD3 FXYD domain containing ion transport regulator 3
GJA1 gap junction protein, alpha 1, 43kDa
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
LAPTM5 lysosomal protein transmembrane 5
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PALMD palmdelphin
PBK PDZ binding kinase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK1 polo-like kinase 1
PLN phospholamban
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
QPRT quinolinate phosphoribosyltransferase
RIN2 Ras and Rab interactor 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIL TLR4 interactor with leucine-rich repeats
VAV3 vav 3 guanine nucleotide exchange factor
ZNF395 zinc finger protein 395