BRD-M86331534_BJM-ctd2-9_RMGI_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_RMGI_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
BTG2 BTG family, member 2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHIC2 cysteine-rich hydrophobic domain 2
CHN2 chimerin 2
CLDND1 claudin domain containing 1
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
COL4A5 collagen, type IV, alpha 5
CPVL carboxypeptidase, vitellogenic-like
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FOXO4 forkhead box O4
GADD45A growth arrest and DNA-damage-inducible, alpha
GPATCH8 G patch domain containing 8
GSTM3 glutathione S-transferase mu 3 (brain)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPB8 heat shock 22kDa protein 8
IL6 interleukin 6
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KIAA0907 KIAA0907
KLHL21 kelch-like family member 21
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MORC4 MORC family CW-type zinc finger 4
MT1M metallothionein 1M
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOTCH2NL notch 2 N-terminal like
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PALLD palladin, cytoskeletal associated protein
PAQR6 progestin and adipoQ receptor family member VI
PIH1D1 PIH1 domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNN pinin, desmosome associated protein
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS2 regulator of G-protein signaling 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A6 solute carrier family 16, member 6
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOD2 superoxide dismutase 2, mitochondrial
SRSF7 serine/arginine-rich splicing factor 7
SSR1 signal sequence receptor, alpha
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
UGDH UDP-glucose 6-dehydrogenase
VNN1 vanin 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
BCL2A1 BCL2-related protein A1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CD200 CD200 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRIP2 cysteine-rich protein 2
FBXO11 F-box protein 11
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GRWD1 glutamate-rich WD repeat containing 1
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
KIAA0101 KIAA0101
MALL mal, T-cell differentiation protein-like
MGLL monoglyceride lipase
MPO myeloperoxidase
PCNA proliferating cell nuclear antigen
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RAD23B RAD23 homolog B (S. cerevisiae)
RFTN1 raftlin, lipid raft linker 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHB Src homology 2 domain containing adaptor protein B
SMAD7 SMAD family member 7
SORBS1 sorbin and SH3 domain containing 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX11 SRY (sex determining region Y)-box 11
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFR2 transferrin receptor 2
TRIB2 tribbles pseudokinase 2
TUBB tubulin, beta class I
TXNDC9 thioredoxin domain containing 9