BRD-M86331534_BJM-ctd2-9_RKO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_RKO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARMCX3 armadillo repeat containing, X-linked 3
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BICC1 BicC family RNA binding protein 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSRP1 cysteine and glycine-rich protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECM1 extracellular matrix protein 1
EGR2 early growth response 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FSD1 fibronectin type III and SPRY domain containing 1
G0S2 G0/G1 switch 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GEM GTP binding protein overexpressed in skeletal muscle
GLA galactosidase, alpha
GREM1 gremlin 1, DAN family BMP antagonist
HOXC6 homeobox C6
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF9 Kruppel-like factor 9
LARP6 La ribonucleoprotein domain family, member 6
LIF leukemia inhibitory factor
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MOXD1 monooxygenase, DBH-like 1
MPO myeloperoxidase
MYRF myelin regulatory factor
NAP1L1 nucleosome assembly protein 1-like 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NRBF2 nuclear receptor binding factor 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPL1 nucleoporin like 1
PDLIM5 PDZ and LIM domain 5
PELI1 pellino E3 ubiquitin protein ligase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSD3 pleckstrin and Sec7 domain containing 3
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
QKI QKI, KH domain containing, RNA binding
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAN RAN, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGCC regulator of cell cycle
RIPK2 receptor-interacting serine-threonine kinase 2
SAV1 salvador family WW domain containing protein 1
SCG5 secretogranin V
SERINC5 serine incorporator 5
SFRP4 secreted frizzled-related protein 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A2 solute carrier family 38, member 2
SOD2 superoxide dismutase 2, mitochondrial
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
VNN1 vanin 1
ZMAT3 zinc finger, matrin-type 3
ZNF165 zinc finger protein 165
ZNF185 zinc finger protein 185 (LIM domain)
ZNF281 zinc finger protein 281

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AHNAK2 AHNAK nucleoprotein 2
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BPHL biphenyl hydrolase-like (serine hydrolase)
BST2 bone marrow stromal cell antigen 2
C11ORF95 chromosome 11 open reading frame 95
CCNF cyclin F
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COL18A1 collagen, type XVIII, alpha 1
CP ceruloplasmin (ferroxidase)
CXCL13 chemokine (C-X-C motif) ligand 13
DES desmin
DHRS11 dehydrogenase/reductase (SDR family) member 11
EDNRA endothelin receptor type A
FAM8A1 family with sequence similarity 8, member A1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
KANK1 KN motif and ankyrin repeat domains 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAPTM4B lysosomal protein transmembrane 4 beta
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS9 lectin, galactoside-binding, soluble, 9
MARCKS myristoylated alanine-rich protein kinase C substrate
MEF2C myocyte enhancer factor 2C
NNAT neuronatin
NR2F6 nuclear receptor subfamily 2, group F, member 6
OBSL1 obscurin-like 1
PALMD palmdelphin
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PLSCR3 phospholipid scramblase 3
PRR5 proline rich 5 (renal)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RNF167 ring finger protein 167
S100A8 S100 calcium binding protein A8
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SFN stratifin
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCTA T-cell leukemia translocation altered
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TUBB2A tubulin, beta 2A class IIa
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1
ZNF512B zinc finger protein 512B