BRD-M86331534_BJM-ctd2-9_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

429 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BRD4 bromodomain containing 4
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCDC92 coiled-coil domain containing 92
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CCNL1 cyclin L1
CD24 CD24 molecule
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLDND1 claudin domain containing 1
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CYBRD1 cytochrome b reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DAAM2 dishevelled associated activator of morphogenesis 2
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DYNLT3 dynein, light chain, Tctex-type 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN1 endothelin 1
EGFL6 EGF-like-domain, multiple 6
EIF1 eukaryotic translation initiation factor 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FKBP11 FK506 binding protein 11, 19 kDa
FOXO4 forkhead box O4
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD10 frizzled class receptor 10
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GARS glycyl-tRNA synthetase
GBP1 guanylate binding protein 1, interferon-inducible
GMFG glia maturation factor, gamma
GPX3 glutathione peroxidase 3
GPX7 glutathione peroxidase 7
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
GSPT2 G1 to S phase transition 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HBB hemoglobin, beta
HCP5 HLA complex P5 (non-protein coding)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-B major histocompatibility complex, class I, B
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ITM2B integral membrane protein 2B
JOSD1 Josephin domain containing 1
KRT17 keratin 17, type I
LAMP3 lysosomal-associated membrane protein 3
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
MMP19 matrix metallopeptidase 19
MSLN mesothelin
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRAF2 PRA1 domain family, member 2
PRAME preferentially expressed antigen in melanoma
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF11 ring finger protein 11
RSAD2 radical S-adenosyl methionine domain containing 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC3 syndecan 3
SEC62 SEC62 homolog (S. cerevisiae)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK1 salt-inducible kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SST somatostatin
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TDO2 tryptophan 2,3-dioxygenase
TERF2IP telomeric repeat binding factor 2, interacting protein
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TICAM1 toll-like receptor adaptor molecule 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM204 transmembrane protein 204
TMEM59 transmembrane protein 59
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOB1 transducer of ERBB2, 1
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TST thiosulfate sulfurtransferase (rhodanese)
TWIST1 twist family bHLH transcription factor 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WBP5 WW domain binding protein 5
WDR45 WD repeat domain 45
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTN1 actinin, alpha 1
ADGRG6 adhesion G protein-coupled receptor G6
ADK adenosine kinase
AFF1 AF4/FMR2 family, member 1
AHNAK AHNAK nucleoprotein
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ANO10 anoctamin 10
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID1A AT rich interactive domain 1A (SWI-like)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ASF1A anti-silencing function 1A histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATF6 activating transcription factor 6
AURKA aurora kinase A
AURKB aurora kinase B
B3GNT1
BARD1 BRCA1 associated RING domain 1
BASP1 brain abundant, membrane attached signal protein 1
BLM Bloom syndrome, RecQ helicase-like
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD5 C2 calcium-dependent domain containing 5
CAPN6 calpain 6
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK19 cyclin-dependent kinase 19
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP350 centrosomal protein 350kDa
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
COL4A2 collagen, type IV, alpha 2
CPD carboxypeptidase D
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSC cathepsin C
CYFIP1 cytoplasmic FMR1 interacting protein 1
DAAM1 dishevelled associated activator of morphogenesis 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DET1 de-etiolated homolog 1 (Arabidopsis)
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DLG5 discs, large homolog 5 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELAVL1 ELAV like RNA binding protein 1
ELOVL2 ELOVL fatty acid elongase 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPS8 epidermal growth factor receptor pathway substrate 8
FAM64A family with sequence similarity 64, member A
FAR2 fatty acyl CoA reductase 2
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMDS GDP-mannose 4,6-dehydratase
GPSM2 G-protein signaling modulator 2
GRB14 growth factor receptor-bound protein 14
HADH hydroxyacyl-CoA dehydrogenase
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXC10 homeobox C10
HSPA8 heat shock 70kDa protein 8
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JARID2 jumonji, AT rich interactive domain 2
KAT6B K(lysine) acetyltransferase 6B
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPP LIM domain containing preferred translocation partner in lipoma
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC16A leucine rich repeat containing 16A
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MATN2 matrilin 2
MBNL1 muscleblind-like splicing regulator 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MKL2 MKL/myocardin-like 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
MYOF myoferlin
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NNT nicotinamide nucleotide transhydrogenase
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUSAP1 nucleolar and spindle associated protein 1
PAM peptidylglycine alpha-amidating monooxygenase
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDS5B PDS5 cohesin associated factor B
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PEBP1 phosphatidylethanolamine binding protein 1
PFKP phosphofructokinase, platelet
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAG1 pleiomorphic adenoma gene 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPARG peroxisome proliferator-activated receptor gamma
PRC1 protein regulator of cytokinesis 1
PRKCA protein kinase C, alpha
PSD3 pleckstrin and Sec7 domain containing 3
PSRC1 proline/serine-rich coiled-coil 1
PTDSS1 phosphatidylserine synthase 1
PTK2 protein tyrosine kinase 2
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
RACGAP1 Rac GTPase activating protein 1
RBBP4 retinoblastoma binding protein 4
RBMX RNA binding motif protein, X-linked
RBPMS RNA binding protein with multiple splicing
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETBP1 SET binding protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SMAD3 SMAD family member 3
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMC4 structural maintenance of chromosomes 4
SORBS1 sorbin and SH3 domain containing 1
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPTBN1 spectrin, beta, non-erythrocytic 1
ST7 suppression of tumorigenicity 7
STK39 serine threonine kinase 39
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SVIL supervillin
TACC2 transforming, acidic coiled-coil containing protein 2
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D4 TBC1 domain family, member 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDP1 tyrosyl-DNA phosphodiesterase 1
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM100 transmembrane protein 100
TMEM131 transmembrane protein 131
TMPO thymopoietin
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TPX2 TPX2, microtubule-associated
TRIM24 tripartite motif containing 24
TRIO trio Rho guanine nucleotide exchange factor
TRIP13 thyroid hormone receptor interactor 13
TRRAP transformation/transcription domain-associated protein
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTK TTK protein kinase
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR5 ubiquitin protein ligase E3 component n-recognin 5
VCL vinculin
VRK1 vaccinia related kinase 1
VWA8 von Willebrand factor A domain containing 8
WDFY3 WD repeat and FYVE domain containing 3
WWTR1 WW domain containing transcription regulator 1
XPO1 exportin 1
ZC3H4 zinc finger CCCH-type containing 4
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF652 zinc finger protein 652
ZWINT ZW10 interacting kinetochore protein