BRD-M86331534_BJM-ctd2-9_OV7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_OV7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
C5AR1 complement component 5a receptor 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CLDN3 claudin 3
CPE carboxypeptidase E
CREM cAMP responsive element modulator
CXCL2 chemokine (C-X-C motif) ligand 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DPT dermatopontin
DSC2 desmocollin 2
EGR2 early growth response 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGL2 fibrinogen-like 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA2 GATA binding protein 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8A golgin A8 family, member A
GRB10 growth factor receptor-bound protein 10
GRB7 growth factor receptor-bound protein 7
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HBB hemoglobin, beta
HIST1H2AC histone cluster 1, H2ac
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
ISYNA1 inositol-3-phosphate synthase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
KLF5 Kruppel-like factor 5 (intestinal)
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
MBNL2 muscleblind-like splicing regulator 2
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO1D myosin ID
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
SCARB2 scavenger receptor class B, member 2
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TIMP2 TIMP metallopeptidase inhibitor 2
TMSB15A thymosin beta 15a
TSPAN6 tetraspanin 6
TWIST1 twist family bHLH transcription factor 1
USP6NL USP6 N-terminal like
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACTB actin, beta
AHNAK2 AHNAK nucleoprotein 2
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARMT1 acidic residue methyltransferase 1
ASCL1 achaete-scute family bHLH transcription factor 1
BAG2 BCL2-associated athanogene 2
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CHGB chromogranin B
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
CTSC cathepsin C
DCT dopachrome tautomerase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNM1L dynamin 1-like
E2F2 E2F transcription factor 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FLNB filamin B, beta
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMGA2 high mobility group AT-hook 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPB1 heat shock 27kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KDM5D lysine (K)-specific demethylase 5D
KIF2C kinesin family member 2C
KRT15 keratin 15, type I
MET MET proto-oncogene, receptor tyrosine kinase
NPDC1 neural proliferation, differentiation and control, 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDZK1 PDZ domain containing 1
PGM1 phosphoglucomutase 1
PRR7 proline rich 7 (synaptic)
RAD23B RAD23 homolog B (S. cerevisiae)
RPS4Y1 ribosomal protein S4, Y-linked 1
STOM stomatin
TFF1 trefoil factor 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMED9 transmembrane emp24 protein transport domain containing 9
TNC tenascin C
TSPYL5 TSPY-like 5