BRD-M86331534_BJM-ctd2-9_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BIRC3 baculoviral IAP repeat containing 3
BMP7 bone morphogenetic protein 7
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL9A3 collagen, type IX, alpha 3
CTH cystathionine gamma-lyase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND2D DENN/MADD domain containing 2D
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DRAM1 DNA-damage regulated autophagy modulator 1
DSC2 desmocollin 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EIF1 eukaryotic translation initiation factor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA2 EPH receptor A2
EREG epiregulin
F11R F11 receptor
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FGFBP1 fibroblast growth factor binding protein 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GPR87 G protein-coupled receptor 87
HBEGF heparin-binding EGF-like growth factor
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
INPP1 inositol polyphosphate-1-phosphatase
INSIG1 insulin induced gene 1
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KIAA0907 KIAA0907
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LMNA lamin A/C
LYST lysosomal trafficking regulator
MARS methionyl-tRNA synthetase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MOSPD1 motile sperm domain containing 1
MTA1 metastasis associated 1
NAMPT nicotinamide phosphoribosyltransferase
NAV2 neuron navigator 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPN3 opsin 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RND3 Rho family GTPase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAD Ras-related associated with diabetes
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG1 sperm associated antigen 1
STC2 stanniocalcin 2
STK17A serine/threonine kinase 17a
SYNGR3 synaptogyrin 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TARS threonyl-tRNA synthetase
TGFA transforming growth factor, alpha
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WARS tryptophanyl-tRNA synthetase
YBX3 Y box binding protein 3
ZBED2 zinc finger, BED-type containing 2
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
B3GNT1
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
C3 complement component 3
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD14 CD14 molecule
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CENPA centromere protein A
CP ceruloplasmin (ferroxidase)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
EMP2 epithelial membrane protein 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GMFG glia maturation factor, gamma
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA8 heat shock 70kDa protein 8
IQGAP2 IQ motif containing GTPase activating protein 2
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LAPTM5 lysosomal protein transmembrane 5
LMNB1 lamin B1
MCM10 minichromosome maintenance complex component 10
MFAP5 microfibrillar associated protein 5
MKI67 marker of proliferation Ki-67
NCAPH non-SMC condensin I complex, subunit H
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
PEX11A peroxisomal biogenesis factor 11 alpha
PLK1 polo-like kinase 1
PRDX2 peroxiredoxin 2
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC44A4 solute carrier family 44, member 4
SPDEF SAM pointed domain containing ETS transcription factor
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
TARP TCR gamma alternate reading frame protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSTA3 tissue specific transplantation antigen P35B
WFS1 Wolfram syndrome 1 (wolframin)
XIST X inactive specific transcript (non-protein coding)