BRD-M86331534_BJM-ctd2-9_LOVO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_LOVO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ALB albumin
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
FAS Fas cell surface death receptor
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GLA galactosidase, alpha
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOPX HOP homeobox
HOXB2 homeobox B2
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL6ST interleukin 6 signal transducer
ISG20 interferon stimulated exonuclease gene 20kDa
KLF9 Kruppel-like factor 9
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LAMA3 laminin, alpha 3
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
LINC00341 long intergenic non-protein coding RNA 341
LTBP2 latent transforming growth factor beta binding protein 2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
NBPF10 neuroblastoma breakpoint family, member 10
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRCAM neuronal cell adhesion molecule
OPTN optineurin
ORM1 orosomucoid 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG3 paternally expressed 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SELE selectin E
SESN1 sestrin 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STAR steroidogenic acute regulatory protein
SULF1 sulfatase 1
TANK TRAF family member-associated NFKB activator
TCF21 transcription factor 21
TF transferrin
THBS1 thrombospondin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TRIM22 tripartite motif containing 22
TRPS1 trichorhinophalangeal syndrome I
TUBB2B tubulin, beta 2B class IIb
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ACLY ATP citrate lyase
ADGRE5 adhesion G protein-coupled receptor E5
AKAP7 A kinase (PRKA) anchor protein 7
ALOX5 arachidonate 5-lipoxygenase
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AXL AXL receptor tyrosine kinase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIN1 bridging integrator 1
CCNA2 cyclin A2
CCNF cyclin F
CNOT7 CCR4-NOT transcription complex, subunit 7
CTSC cathepsin C
CTSH cathepsin H
CTTN cortactin
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DCK deoxycytidine kinase
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
EIF4B eukaryotic translation initiation factor 4B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FXYD5 FXYD domain containing ion transport regulator 5
FYB FYN binding protein
GLB1 galactosidase, beta 1
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB1 heat shock 27kDa protein 1
IGF1R insulin-like growth factor 1 receptor
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MPZL1 myelin protein zero-like 1
MRPS16 mitochondrial ribosomal protein S16
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDZK1IP1 PDZK1 interacting protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PRPF19 pre-mRNA processing factor 19
PTGDS prostaglandin D2 synthase 21kDa (brain)
QDPR quinoid dihydropteridine reductase
RPIA ribose 5-phosphate isomerase A
RRP1B ribosomal RNA processing 1B
RUVBL2 RuvB-like AAA ATPase 2
SEPT9 septin 9
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SRSF9 serine/arginine-rich splicing factor 9
STMN1 stathmin 1
SUMO3 small ubiquitin-like modifier 3
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D16 TBC1 domain family, member 16
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN1 tectonic family member 1
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM109 transmembrane protein 109
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TUSC3 tumor suppressor candidate 3
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VAMP8 vesicle-associated membrane protein 8
WBSCR22 Williams Beuren syndrome chromosome region 22
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble