BRD-M86331534_BJM-ctd2-9_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM12 ADAM metallopeptidase domain 12
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGR1 early growth response 1
FAM129A family with sequence similarity 129, member A
FAM60A family with sequence similarity 60, member A
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
IL6 interleukin 6
IQCG IQ motif containing G
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KRT17 keratin 17, type I
LARP6 La ribonucleoprotein domain family, member 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
ODC1 ornithine decarboxylase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPEN spen family transcriptional repressor
STC2 stanniocalcin 2
TGIF1 TGFB-induced factor homeobox 1
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIB1 tribbles pseudokinase 1
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein
ZNF22 zinc finger protein 22

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
ANXA4 annexin A4
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASPH aspartate beta-hydroxylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
C9ORF3 chromosome 9 open reading frame 3
CALD1 caldesmon 1
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CD99 CD99 molecule
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
COMP cartilage oligomeric matrix protein
CP ceruloplasmin (ferroxidase)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF5A eukaryotic translation initiation factor 5A
EMP2 epithelial membrane protein 2
EPCAM epithelial cell adhesion molecule
FGFR3 fibroblast growth factor receptor 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
GPNMB glycoprotein (transmembrane) nmb
GTSE1 G-2 and S-phase expressed 1
HMGB3 high mobility group box 3
IFI44L interferon-induced protein 44-like
IGHM immunoglobulin heavy constant mu
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT19 keratin 19, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LPCAT1 lysophosphatidylcholine acyltransferase 1
MCOLN1 mucolipin 1
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
MPZL2 myelin protein zero-like 2
MX1 MX dynamin-like GTPase 1
PALMD palmdelphin
PBX1 pre-B-cell leukemia homeobox 1
PCP4 Purkinje cell protein 4
PDLIM1 PDZ and LIM domain 1
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRKCB protein kinase C, beta
PSRC1 proline/serine-rich coiled-coil 1
PTK2 protein tyrosine kinase 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SORBS1 sorbin and SH3 domain containing 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPYL5 TSPY-like 5
TTC3 tetratricopeptide repeat domain 3
TUBB4B tubulin, beta 4B class IVb
ZMIZ1 zinc finger, MIZ-type containing 1