BRD-M86331534_BJM-ctd2-9_COV644_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_COV644_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CECR1 cat eye syndrome chromosome region, candidate 1
CLCA4 chloride channel accessory 4
CPE carboxypeptidase E
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DACH1 dachshund family transcription factor 1
DLX2 distal-less homeobox 2
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP1 fatty acid binding protein 1, liver
FBP1 fructose-1,6-bisphosphatase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF2 forkhead box F2
FST follistatin
FZD10 frizzled class receptor 10
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL6 interleukin 6
INHBA inhibin, beta A
INSM1 insulinoma-associated 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LEF1 lymphoid enhancer-binding factor 1
LYZ lysozyme
MT1X metallothionein 1X
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLCB4 phospholipase C, beta 4
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPRC protein tyrosine phosphatase, receptor type, C
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A10 S100 calcium binding protein A10
S100P S100 calcium binding protein P
SGK1 serum/glucocorticoid regulated kinase 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SOX11 SRY (sex determining region Y)-box 11
SRGN serglycin
STC1 stanniocalcin 1
SULF1 sulfatase 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZFP36 ZFP36 ring finger protein
ZFPM2 zinc finger protein, FOG family member 2
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CAPNS1 calpain, small subunit 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOC7 exocyst complex component 7
FOXJ3 forkhead box J3
GLB1 galactosidase, beta 1
HN1 hematological and neurological expressed 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA8 heat shock 70kDa protein 8
ICA1 islet cell autoantigen 1, 69kDa
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITM2A integral membrane protein 2A
KANK2 KN motif and ankyrin repeat domains 2
KLHL21 kelch-like family member 21
LAMC1 laminin, gamma 1 (formerly LAMB2)
LASP1 LIM and SH3 protein 1
LIG1 ligase I, DNA, ATP-dependent
LTBP3 latent transforming growth factor beta binding protein 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGED1 melanoma antigen family D1
METRN meteorin, glial cell differentiation regulator
MICALL1 MICAL-like 1
MXRA7 matrix-remodelling associated 7
NCOA4 nuclear receptor coactivator 4
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPC2 Niemann-Pick disease, type C2
NPTXR neuronal pentraxin receptor
NPY neuropeptide Y
NUP85 nucleoporin 85kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PFKP phosphofructokinase, platelet
PRKCB protein kinase C, beta
PROM1 prominin 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SEPT9 septin 9
SEPW1 selenoprotein W, 1
SET SET nuclear proto-oncogene
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLIRP SRA stem-loop interacting RNA binding protein
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRSF6 serine/arginine-rich splicing factor 6
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM47 transmembrane protein 47
TRIM28 tripartite motif containing 28
TRIOBP TRIO and F-actin binding protein
TRIP6 thyroid hormone receptor interactor 6
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TSTA3 tissue specific transplantation antigen P35B
TUBB tubulin, beta class I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WRB tryptophan rich basic protein
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble