BRD-M86331534_BJM-ctd2-9_CL34_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_CL34_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
AREG amphiregulin
ARGLU1 arginine and glutamate rich 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C7 complement component 7
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNL1 cyclin L1
CD24 CD24 molecule
CD52 CD52 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL14A1 collagen, type XIV, alpha 1
COL15A1 collagen, type XV, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FUBP1 far upstream element (FUSE) binding protein 1
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-G major histocompatibility complex, class I, G
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL6 interleukin 6
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KIAA0907 KIAA0907
KLHL21 kelch-like family member 21
LDLR low density lipoprotein receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS2 Meis homeobox 2
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR4A1 nuclear receptor subfamily 4, group A, member 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P3H2 prolyl 3-hydroxylase 2
PAIP1 poly(A) binding protein interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNISR PNN-interacting serine/arginine-rich protein
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER3 prostaglandin E receptor 3 (subtype EP3)
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAI2 snail family zinc finger 2
SPARCL1 SPARC-like 1 (hevin)
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TBX3 T-box 3
TES testin LIM domain protein
TFPI2 tissue factor pathway inhibitor 2
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRA2A transformer 2 alpha homolog (Drosophila)
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
UBQLN2 ubiquilin 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACAT2 acetyl-CoA acetyltransferase 2
AGR2 anterior gradient 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANPEP alanyl (membrane) aminopeptidase
ARFIP2 ADP-ribosylation factor interacting protein 2
B3GNT1
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDK6 cyclin-dependent kinase 6
CENPA centromere protein A
CSK c-src tyrosine kinase
EBP emopamil binding protein (sterol isomerase)
EXOSC4 exosome component 4
FCGBP Fc fragment of IgG binding protein
GMDS GDP-mannose 4,6-dehydratase
HOXC10 homeobox C10
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCTD12 potassium channel tetramerization domain containing 12
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTBP1 latent transforming growth factor beta binding protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MRPL17 mitochondrial ribosomal protein L17
MTCH2 mitochondrial carrier 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NT5DC2 5'-nucleotidase domain containing 2
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PON2 paraoxonase 2
RAD51C RAD51 paralog C
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SYNGR2 synaptogyrin 2
THBS1 thrombospondin 1