BRD-M86331534_BJM-ctd2-9_A673_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADAMDEC1 ADAM-like, decysin 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ANKRD10 ankyrin repeat domain 10
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CCL5 chemokine (C-C motif) ligand 5
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CGRRF1 cell growth regulator with ring finger domain 1
CLDN1 claudin 1
CTH cystathionine gamma-lyase
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EHF ets homologous factor
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FKBP11 FK506 binding protein 11, 19 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS1 growth arrest-specific 1
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GRAMD3 GRAM domain containing 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGLV2-23 immunoglobulin lambda variable 2-23
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUND jun D proto-oncogene
KIAA0907 KIAA0907
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
MXI1 MAX interactor 1, dimerization protein
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
RABGGTB Rab geranylgeranyltransferase, beta subunit
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOB ras homolog family member B
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIK1 salt-inducible kinase 1
SQSTM1 sequestosome 1
STAP2 signal transducing adaptor family member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TBX3 T-box 3
TLR4 toll-like receptor 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP63 tumor protein p63
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TUFT1 tuftelin 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
ACAN aggrecan
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD1 adducin 1 (alpha)
ADGRF5 adhesion G protein-coupled receptor F5
AHNAK2 AHNAK nucleoprotein 2
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
CA12 carbonic anhydrase XII
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC85B coiled-coil domain containing 85B
CCNF cyclin F
CD93 CD93 molecule
CDA cytidine deaminase
CHI3L2 chitinase 3-like 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CPD carboxypeptidase D
CTSA cathepsin A
DHDDS dehydrodolichyl diphosphate synthase
DPYSL2 dihydropyrimidinase-like 2
EDNRA endothelin receptor type A
ELN elastin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GPSM2 G-protein signaling modulator 2
HILPDA hypoxia inducible lipid droplet-associated
HSDL2 hydroxysteroid dehydrogenase like 2
IGF1R insulin-like growth factor 1 receptor
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
KIF20A kinesin family member 20A
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPL lipoprotein lipase
MAN1C1 mannosidase, alpha, class 1C, member 1
MKL2 MKL/myocardin-like 2
NDNF neuron-derived neurotrophic factor
NID2 nidogen 2 (osteonidogen)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PHACTR2 phosphatase and actin regulator 2
PLK1 polo-like kinase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PSRC1 proline/serine-rich coiled-coil 1
REEP1 receptor accessory protein 1
S100P S100 calcium binding protein P
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORT1 sortilin 1
SPRED2 sprouty-related, EVH1 domain containing 2
THBD thrombomodulin
UBE2C ubiquitin-conjugating enzyme E2C
VWF von Willebrand factor