BRD-M86331534_BJM-ctd2-9_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

263 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADIRF adipogenesis regulatory factor
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARMCX1 armadillo repeat containing, X-linked 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAX BCL2-associated X protein
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CAPG capping protein (actin filament), gelsolin-like
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN3 claudin 3
COL9A3 collagen, type IX, alpha 3
CTTN cortactin
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
FADS3 fatty acid desaturase 3
FAS Fas cell surface death receptor
FBP1 fructose-1,6-bisphosphatase 1
FDXR ferredoxin reductase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IL17RB interleukin 17 receptor B
IL6 interleukin 6
INPP1 inositol polyphosphate-1-phosphatase
IQCG IQ motif containing G
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT17 keratin 17, type I
KRT18 keratin 18, type I
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOB monoamine oxidase B
MCL1 myeloid cell leukemia 1
MT1E metallothionein 1E
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ORM1 orosomucoid 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RPS27L ribosomal protein S27-like
RRAD Ras-related associated with diabetes
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIK1 salt-inducible kinase 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAGLN2 transgelin 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMEM176B transmembrane protein 176B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BIRC5 baculoviral IAP repeat containing 5
BLCAP bladder cancer associated protein
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CEP68 centrosomal protein 68kDa
CKAP2 cytoskeleton associated protein 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DEGS1 delta(4)-desaturase, sphingolipid 1
DES desmin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM111A family with sequence similarity 111, member A
FAM64A family with sequence similarity 64, member A
FRZB frizzled-related protein
GAS1 growth arrest-specific 1
GPSM2 G-protein signaling modulator 2
GTSE1 G-2 and S-phase expressed 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
HJURP Holliday junction recognition protein
HMGB3 high mobility group box 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44L interferon-induced protein 44-like
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LXN latexin
LYPD1 LY6/PLAUR domain containing 1
MAT2A methionine adenosyltransferase II, alpha
MEF2C myocyte enhancer factor 2C
MKI67 marker of proliferation Ki-67
MKL2 MKL/myocardin-like 2
MSRB1 methionine sulfoxide reductase B1
MYH11 myosin, heavy chain 11, smooth muscle
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NDN necdin, melanoma antigen (MAGE) family member
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PDE10A phosphodiesterase 10A
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK1 polo-like kinase 1
PLN phospholamban
PLXNC1 plexin C1
PRKCB protein kinase C, beta
PTTG1 pituitary tumor-transforming 1
RAB13 RAB13, member RAS oncogene family
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SOX11 SRY (sex determining region Y)-box 11
SPC25 SPC25, NDC80 kinetochore complex component
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM2 tropomyosin 2 (beta)
TPX2 TPX2, microtubule-associated
TRIB2 tribbles pseudokinase 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
WT1 Wilms tumor 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZMIZ1 zinc finger, MIZ-type containing 1