BRD-K99964838_bosutinib_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K99964838_bosutinib_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
BAD BCL2-associated agonist of cell death
BPIFA1 BPI fold containing family A, member 1
CCDC92 coiled-coil domain containing 92
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CFD complement factor D (adipsin)
CLDN10 claudin 10
CPA3 carboxypeptidase A3 (mast cell)
CRIP1 cysteine-rich protein 1 (intestinal)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYBB cytochrome b-245, beta polypeptide
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DCN decorin
DEFB1 defensin, beta 1
ECI1 enoyl-CoA delta isomerase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EVI2B ecotropic viral integration site 2B
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FXYD3 FXYD domain containing ion transport regulator 3
GARS glycyl-tRNA synthetase
GOLM1 golgi membrane protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JAG1 jagged 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF2 Kruppel-like factor 2
KRT19 keratin 19, type I
LCN2 lipocalin 2
LRRC15 leucine rich repeat containing 15
MAPT microtubule-associated protein tau
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLPH melanophilin
MOCOS molybdenum cofactor sulfurase
MSMB microseminoprotein, beta-
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYL9 myosin, light chain 9, regulatory
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
PSAT1 phosphoserine aminotransferase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGCC regulator of cell cycle
RHOA ras homolog family member A
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF187 ring finger protein 187
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SRGN serglycin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAGLN transgelin
TARS threonyl-tRNA synthetase
TCTA T-cell leukemia translocation altered
TMC5 transmembrane channel-like 5
TRAF5 TNF receptor-associated factor 5
TRIB2 tribbles pseudokinase 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BMP2 bone morphogenetic protein 2
CALR calreticulin
CCNA2 cyclin A2
CCNE2 cyclin E2
CD24 CD24 molecule
CDK1 cyclin-dependent kinase 1
CSRP2 cysteine and glycine-rich protein 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNM1L dynamin 1-like
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FST follistatin
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPNMB glycoprotein (transmembrane) nmb
HK1 hexokinase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPH1 heat shock 105kDa/110kDa protein 1
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
KIF20A kinesin family member 20A
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
MYCBP MYC binding protein
NFIB nuclear factor I/B
OPN3 opsin 3
PCNA proliferating cell nuclear antigen
PLTP phospholipid transfer protein
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPL37A ribosomal protein L37a
RRM2 ribonucleotide reductase M2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMC4 structural maintenance of chromosomes 4
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
STOM stomatin
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
VSNL1 visinin-like 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)