BRD-K99818283_PIK-90_THP1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K99818283_PIK-90_THP1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAT1 adenosine deaminase, tRNA-specific 1
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
ARMCX1 armadillo repeat containing, X-linked 1
BLNK B-cell linker
CCNG2 cyclin G2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDK19 cyclin-dependent kinase 19
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
CRABP1 cellular retinoic acid binding protein 1
DPYSL2 dihydropyrimidinase-like 2
EGFL6 EGF-like-domain, multiple 6
EMP2 epithelial membrane protein 2
EPAS1 endothelial PAS domain protein 1
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUSBP3 glucuronidase, beta pseudogene 3
HEPH hephaestin
HNMT histamine N-methyltransferase
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KLHDC2 kelch domain containing 2
LEFTY1 left-right determination factor 1
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MAP3K7CL MAP3K7 C-terminal like
MEF2C myocyte enhancer factor 2C
MT1M metallothionein 1M
MTMR11 myotubularin related protein 11
MUC2 mucin 2, oligomeric mucus/gel-forming
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC1 myosin binding protein C, slow type
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PBX1 pre-B-cell leukemia homeobox 1
PDE1A phosphodiesterase 1A, calmodulin-dependent
PLCB4 phospholipase C, beta 4
PLS3 plastin 3
POSTN periostin, osteoblast specific factor
RTN2 reticulon 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPINK4 serine peptidase inhibitor, Kazal type 4
TARP TCR gamma alternate reading frame protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRPS1 trichorhinophalangeal syndrome I
TXNIP thioredoxin interacting protein
TYRP1 tyrosinase-related protein 1
UBE3B ubiquitin protein ligase E3B
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANPEP alanyl (membrane) aminopeptidase
ASRGL1 asparaginase like 1
ATP13A3 ATPase type 13A3
CCDC86 coiled-coil domain containing 86
CDCA4 cell division cycle associated 4
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DPH2 DPH2 homolog (S. cerevisiae)
EXOSC4 exosome component 4
FAM3C family with sequence similarity 3, member C
FKBP1A FK506 binding protein 1A, 12kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HES1 hes family bHLH transcription factor 1
HOXB2 homeobox B2
INHBA inhibin, beta A
IRF4 interferon regulatory factor 4
KAZN kazrin, periplakin interacting protein
KLK10 kallikrein-related peptidase 10
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MIEF1 mitochondrial elongation factor 1
MRPS2 mitochondrial ribosomal protein S2
NARFL nuclear prelamin A recognition factor-like
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
ODC1 ornithine decarboxylase 1
PLAT plasminogen activator, tissue
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLTP phospholipid transfer protein
PPAT phosphoribosyl pyrophosphate amidotransferase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRNP prion protein
PTDSS1 phosphatidylserine synthase 1
PTRH2 peptidyl-tRNA hydrolase 2
RBP1 retinol binding protein 1, cellular
RHOB ras homolog family member B
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCARB1 scavenger receptor class B, member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC44A4 solute carrier family 44, member 4
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
SRM spermidine synthase
SYBU syntabulin (syntaxin-interacting)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing