BRD-K99818283_PIK-90_SNGM_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K99818283_PIK-90_SNGM_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CFD complement factor D (adipsin)
CHN2 chimerin 2
CNPY3 canopy FGF signaling regulator 3
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
DDAH2 dimethylarginine dimethylaminohydrolase 2
DST dystonin
FAM69A family with sequence similarity 69, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FNBP1 formin binding protein 1
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KLF9 Kruppel-like factor 9
LEF1 lymphoid enhancer-binding factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MBNL2 muscleblind-like splicing regulator 2
MEIS2 Meis homeobox 2
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
NT5E 5'-nucleotidase, ecto (CD73)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCGF3 polycomb group ring finger 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE8A phosphodiesterase 8A
PDGFC platelet derived growth factor C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PYCARD PYD and CARD domain containing
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SERINC5 serine incorporator 5
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SRGN serglycin
TBXA2R thromboxane A2 receptor
THBS2 thrombospondin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACOT7 acyl-CoA thioesterase 7
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA3 annexin A3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BOP1 block of proliferation 1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CLU clusterin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
CYFIP2 cytoplasmic FMR1 interacting protein 2
DPH2 DPH2 homolog (S. cerevisiae)
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FKBP11 FK506 binding protein 11, 19 kDa
G0S2 G0/G1 switch 2
GLS glutaminase
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
ITGB1BP1 integrin beta 1 binding protein 1
KRT10 keratin 10, type I
LRRC59 leucine rich repeat containing 59
MCM10 minichromosome maintenance complex component 10
MFAP5 microfibrillar associated protein 5
MGAM maltase-glucoamylase
MRPL12 mitochondrial ribosomal protein L12
MTCL1 microtubule crosslinking factor 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NTS neurotensin
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
PDIA6 protein disulfide isomerase family A, member 6
PDZK1 PDZ domain containing 1
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
PSPH phosphoserine phosphatase
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RGS4 regulator of G-protein signaling 4
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SACS sacsin molecular chaperone
SCG5 secretogranin V
SEH1L SEH1-like (S. cerevisiae)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SRM spermidine synthase
STIP1 stress-induced phosphoprotein 1
STK39 serine threonine kinase 39
TEX10 testis expressed 10
TFAM transcription factor A, mitochondrial
TFF3 trefoil factor 3 (intestinal)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TOMM34 translocase of outer mitochondrial membrane 34
TXNL4A thioredoxin-like 4A
UBE2S ubiquitin-conjugating enzyme E2S
UBE3C ubiquitin protein ligase E3C
WDR43 WD repeat domain 43