BRD-K99818283_PIK-90_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K99818283_PIK-90_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
APOD apolipoprotein D
CCDC92 coiled-coil domain containing 92
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
GSN gelsolin
IGF1R insulin-like growth factor 1 receptor
LXN latexin
MAPT microtubule-associated protein tau
MVP major vault protein
PF4 platelet factor 4
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRUNE2 prune homolog 2 (Drosophila)
RTN2 reticulon 2
SEPP1 selenoprotein P, plasma, 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)

decreased expression

Symbol Name
AK4 adenylate kinase 4
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
EGLN3 egl-9 family hypoxia-inducible factor 3
FADS1 fatty acid desaturase 1
GCH1 GTP cyclohydrolase 1
HSPA14 heat shock 70kDa protein 14
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KLHL7 kelch-like family member 7
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NOP56 NOP56 ribonucleoprotein
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PFKP phosphofructokinase, platelet
PLAGL1 pleiomorphic adenoma gene-like 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFRC transferrin receptor
TUBB2A tubulin, beta 2A class IIa