BRD-K99818283_PIK-90_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K99818283_PIK-90_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AMOTL2 angiomotin like 2
ANXA4 annexin A4
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ATP9A ATPase, class II, type 9A
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GALC galactosylceramidase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GRN granulin
GSN gelsolin
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
INSR insulin receptor
ITGB5 integrin, beta 5
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA1324 KIAA1324
LITAF lipopolysaccharide-induced TNF factor
LRP10 low density lipoprotein receptor-related protein 10
MMP7 matrix metallopeptidase 7
MYLIP myosin regulatory light chain interacting protein
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
P3H2 prolyl 3-hydroxylase 2
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PNRC1 proline-rich nuclear receptor coactivator 1
RNF103 ring finger protein 103
RPL22 ribosomal protein L22
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SH3YL1 SH3 and SYLF domain containing 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SMAD3 SMAD family member 3
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TRAPPC6A trafficking protein particle complex 6A
TXNIP thioredoxin interacting protein
VIM vimentin
WDR45 WD repeat domain 45
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BIRC5 baculoviral IAP repeat containing 5
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPN centromere protein N
CKS2 CDC28 protein kinase regulatory subunit 2
CMC2 C-x(9)-C motif containing 2
COMMD8 COMM domain containing 8
CXCL13 chemokine (C-X-C motif) ligand 13
DBF4 DBF4 zinc finger
DCLK1 doublecortin-like kinase 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
ENO2 enolase 2 (gamma, neuronal)
G0S2 G0/G1 switch 2
GAS2L1 growth arrest-specific 2 like 1
GPC3 glypican 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF14 kinesin family member 14
LMO4 LIM domain only 4
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCAPG non-SMC condensin I complex, subunit G
PBK PDZ binding kinase
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SEC23A Sec23 homolog A (S. cerevisiae)
SPTSSA serine palmitoyltransferase, small subunit A
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)