BRD-K99818283_PIK-90_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K99818283_PIK-90_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ANKRD36B ankyrin repeat domain 36B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CES1 carboxylesterase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAPK1 death-associated protein kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
GPX4 glutathione peroxidase 4
GRN granulin
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IRS1 insulin receptor substrate 1
KLHDC2 kelch domain containing 2
N4BP2L1 NEDD4 binding protein 2-like 1
NT5E 5'-nucleotidase, ecto (CD73)
OPN3 opsin 3
OXTR oxytocin receptor
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLA2G16 phospholipase A2, group XVI
PLS3 plastin 3
PNMA2 paraneoplastic Ma antigen 2
PNRC1 proline-rich nuclear receptor coactivator 1
RNASE4 ribonuclease, RNase A family, 4
SELL selectin L
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
CALML3 calmodulin-like 3
CCL2 chemokine (C-C motif) ligand 2
CLCA1 chloride channel accessory 1
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DSG3 desmoglein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FOSL1 FOS-like antigen 1
FOXF1 forkhead box F1
FRZB frizzled-related protein
HES1 hes family bHLH transcription factor 1
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IGKV1-5 immunoglobulin kappa variable 1-5
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MMP12 matrix metallopeptidase 12
ODC1 ornithine decarboxylase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTX3 pentraxin 3, long
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SPON1 spondin 1, extracellular matrix protein
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)