BRD-K99818283_PIK-90_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-K99818283_PIK-90_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP2 cellular retinoic acid binding protein 2
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DRAM1 DNA-damage regulated autophagy modulator 1
EIF5A eukaryotic translation initiation factor 5A
ERBB3 erb-b2 receptor tyrosine kinase 3
FST follistatin
GBP2 guanylate binding protein 2, interferon-inducible
GSN gelsolin
IGFBP3 insulin-like growth factor binding protein 3
LPAR2 lysophosphatidic acid receptor 2
MVP major vault protein
PDLIM5 PDZ and LIM domain 5
POLR1D polymerase (RNA) I polypeptide D, 16kDa
SLC38A2 solute carrier family 38, member 2
SPRED2 sprouty-related, EVH1 domain containing 2
TCTN1 tectonic family member 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPM6B glycoprotein M6B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IGHD immunoglobulin heavy constant delta
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PSRC1 proline/serine-rich coiled-coil 1
SDF2L1 stromal cell-derived factor 2-like 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
VLDLR very low density lipoprotein receptor