BRD-K99749624_linifanib_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K99749624_linifanib_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM28 ADAM metallopeptidase domain 28
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
CBR3 carbonyl reductase 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
EGFR epidermal growth factor receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FN1 fibronectin 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMB microseminoprotein, beta-
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
SCG5 secretogranin V
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SHROOM2 shroom family member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
TMC5 transmembrane channel-like 5
TOB1 transducer of ERBB2, 1
TSC22D1 TSC22 domain family, member 1
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
ANKRD36B ankyrin repeat domain 36B
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CAV1 caveolin 1, caveolae protein, 22kDa
CTGF connective tissue growth factor
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
EMX2 empty spiracles homeobox 2
FAM3C family with sequence similarity 3, member C
GLDC glycine dehydrogenase (decarboxylating)
GOLGA8A golgin A8 family, member A
GUSBP3 glucuronidase, beta pseudogene 3
JADE2 jade family PHD finger 2
KRT6B keratin 6B, type II
MAN1A1 mannosidase, alpha, class 1A, member 1
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
NELL2 NEL-like 2 (chicken)
NRCAM neuronal cell adhesion molecule
PCP4 Purkinje cell protein 4
PERP PERP, TP53 apoptosis effector
PLS3 plastin 3
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS4 regulator of G-protein signaling 4
RND3 Rho family GTPase 3
SCML1 sex comb on midleg-like 1 (Drosophila)
SFRP1 secreted frizzled-related protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
STK26 serine/threonine protein kinase 26
SYT1 synaptotagmin I
TES testin LIM domain protein
TPD52L1 tumor protein D52-like 1