BRD-K99749624_linifanib_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K99749624_linifanib_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C3 complement component 3
CD24 CD24 molecule
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL10A1 collagen, type X, alpha 1
COL14A1 collagen, type XIV, alpha 1
COMP cartilage oligomeric matrix protein
CYB5R2 cytochrome b5 reductase 2
DCLK1 doublecortin-like kinase 1
EFHD1 EF-hand domain family, member D1
FAM46A family with sequence similarity 46, member A
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H4C histone cluster 1, H4c
HOXC6 homeobox C6
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INHBA inhibin, beta A
LAMP5 lysosomal-associated membrane protein family, member 5
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MTUS1 microtubule associated tumor suppressor 1
NFIB nuclear factor I/B
PDLIM5 PDZ and LIM domain 5
PTMA prothymosin, alpha
RCAN1 regulator of calcineurin 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCGB2A2 secretoglobin, family 2A, member 2
SCRG1 stimulator of chondrogenesis 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFN stratifin
SFTPB surfactant protein B
SORBS2 sorbin and SH3 domain containing 2
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
STOM stomatin
SYT1 synaptotagmin I
TAGLN transgelin
TMEM176B transmembrane protein 176B
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL5A1 collagen, type V, alpha 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPEP glutamyl aminopeptidase (aminopeptidase A)
HCAR3 hydroxycarboxylic acid receptor 3
IL1B interleukin 1, beta
KDM5D lysine (K)-specific demethylase 5D
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LYPD1 LY6/PLAUR domain containing 1
MME membrane metallo-endopeptidase
MTCL1 microtubule crosslinking factor 1
NMU neuromedin U
OPN3 opsin 3
P3H2 prolyl 3-hydroxylase 2
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSPH phosphoserine phosphatase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A46 solute carrier family 25, member 46
TBC1D31 TBC1 domain family, member 31
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
WNT5A wingless-type MMTV integration site family, member 5A