BRD-K99633092_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K99633092_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL3 B-cell CLL/lymphoma 3
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CD163 CD163 molecule
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CGRRF1 cell growth regulator with ring finger domain 1
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
FOSL1 FOS-like antigen 1
FZD6 frizzled class receptor 6
GCLC glutamate-cysteine ligase, catalytic subunit
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IGHM immunoglobulin heavy constant mu
KIAA0226L KIAA0226-like
KLHL24 kelch-like family member 24
KRT6A keratin 6A, type II
LAPTM4B lysosomal protein transmembrane 4 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP9 matrix metallopeptidase 9
MUC5B mucin 5B, oligomeric mucus/gel-forming
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PLK2 polo-like kinase 2
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
SFN stratifin
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOWAHC sosondowah ankyrin repeat domain family member C
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAA1 acetyl-CoA acyltransferase 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
AGTR1 angiotensin II receptor, type 1
ALDOB aldolase B, fructose-bisphosphate
AMBP alpha-1-microglobulin/bikunin precursor
APOC3 apolipoprotein C-III
C7 complement component 7
CIRBP cold inducible RNA binding protein
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCXR dicarbonyl/L-xylulose reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPT dermatopontin
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GLDC glycine dehydrogenase (decarboxylating)
GMDS GDP-mannose 4,6-dehydratase
GPX3 glutathione peroxidase 3
IL17RB interleukin 17 receptor B
IL33 interleukin 33
ITM2A integral membrane protein 2A
LEPR leptin receptor
MARCKSL1 MARCKS-like 1
METTL7A methyltransferase like 7A
PAH phenylalanine hydroxylase
PDZK1 PDZ domain containing 1
PEBP1 phosphatidylethanolamine binding protein 1
POSTN periostin, osteoblast specific factor
PTGIS prostaglandin I2 (prostacyclin) synthase
RBP4 retinol binding protein 4, plasma
RELN reelin
SCGB2A2 secretoglobin, family 2A, member 2
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TJP2 tight junction protein 2
TLR4 toll-like receptor 4
TMPRSS3 transmembrane protease, serine 3
UBE2C ubiquitin-conjugating enzyme E2C
VNN1 vanin 1