BRD-K99545815_PF-562271_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K99545815_PF-562271_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
CES1 carboxylesterase 1
COL11A1 collagen, type XI, alpha 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
GAS7 growth arrest-specific 7
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXC6 homeobox C6
JADE2 jade family PHD finger 2
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
MLF1 myeloid leukemia factor 1
MYH11 myosin, heavy chain 11, smooth muscle
NELL2 NEL-like 2 (chicken)
NRIP1 nuclear receptor interacting protein 1
PIP prolactin-induced protein
PPOX protoporphyrinogen oxidase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
REEP1 receptor accessory protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNAP25 synaptosomal-associated protein, 25kDa
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN2 stathmin 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AURKA aurora kinase A
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANT1 calcium activated nucleotidase 1
CDC25B cell division cycle 25B
CDKN2A cyclin-dependent kinase inhibitor 2A
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
EIF5 eukaryotic translation initiation factor 5
FAS Fas cell surface death receptor
FSTL1 follistatin-like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IL1R1 interleukin 1 receptor, type I
KAZN kazrin, periplakin interacting protein
KLK5 kallikrein-related peptidase 5
MED13 mediator complex subunit 13
NFIB nuclear factor I/B
NUP85 nucleoporin 85kDa
OPN3 opsin 3
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
RAD21 RAD21 homolog (S. pombe)
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
TFPI2 tissue factor pathway inhibitor 2
TMX4 thioredoxin-related transmembrane protein 4
TYMS thymidylate synthetase
VGLL1 vestigial-like family member 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1