BRD-K99545815_PF-562271_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K99545815_PF-562271_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
APOA1 apolipoprotein A-I
ASCL1 achaete-scute family bHLH transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BGN biglycan
CD59 CD59 molecule, complement regulatory protein
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFL6 EGF-like-domain, multiple 6
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EPHA3 EPH receptor A3
FLRT3 fibronectin leucine rich transmembrane protein 3
FOS FBJ murine osteosarcoma viral oncogene homolog
GAB2 GRB2-associated binding protein 2
GM2A GM2 ganglioside activator
HIST1H2BK histone cluster 1, H2bk
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
KDM5B lysine (K)-specific demethylase 5B
KNG1 kininogen 1
L1CAM L1 cell adhesion molecule
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MAMLD1 mastermind-like domain containing 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
METTL7A methyltransferase like 7A
MFAP4 microfibrillar-associated protein 4
NDRG1 N-myc downstream regulated 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM1 olfactomedin 1
PCOLCE procollagen C-endopeptidase enhancer
PRAME preferentially expressed antigen in melanoma
PTN pleiotrophin
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS11 ribosomal protein S11
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SMAD1 SMAD family member 1
SPRR1A small proline-rich protein 1A
SRSF5 serine/arginine-rich splicing factor 5
STK17A serine/threonine kinase 17a
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TCEA2 transcription elongation factor A (SII), 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TNC tenascin C
TUBB2A tubulin, beta 2A class IIa
VIM vimentin
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADIRF adipogenesis regulatory factor
AK5 adenylate kinase 5
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
BHLHE41 basic helix-loop-helix family, member e41
CAPNS1 calpain, small subunit 1
CD69 CD69 molecule
CELF2 CUGBP, Elav-like family member 2
CLEC11A C-type lectin domain family 11, member A
COA3 cytochrome c oxidase assembly factor 3
CRELD2 cysteine-rich with EGF-like domains 2
CTGF connective tissue growth factor
CXCL11 chemokine (C-X-C motif) ligand 11
DHRS3 dehydrogenase/reductase (SDR family) member 3
EIF1 eukaryotic translation initiation factor 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FXYD5 FXYD domain containing ion transport regulator 5
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KANK1 KN motif and ankyrin repeat domains 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LOX lysyl oxidase
LY75 lymphocyte antigen 75
MEGF9 multiple EGF-like-domains 9
MUC4 mucin 4, cell surface associated
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NQO1 NAD(P)H dehydrogenase, quinone 1
PGRMC2 progesterone receptor membrane component 2
PLAGL1 pleiomorphic adenoma gene-like 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PSENEN presenilin enhancer gamma secretase subunit
PTCH1 patched 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB21 RAB21, member RAS oncogene family
RRAGA Ras-related GTP binding A
S100P S100 calcium binding protein P
SATB1 SATB homeobox 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SMC1A structural maintenance of chromosomes 1A
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM147 transmembrane protein 147
TPBG trophoblast glycoprotein
TSPO translocator protein (18kDa)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)