BRD-K99545815_PF-562271_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K99545815_PF-562271_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA1 annexin A1
ANXA3 annexin A3
APOD apolipoprotein D
AUTS2 autism susceptibility candidate 2
BMP2 bone morphogenetic protein 2
CAV2 caveolin 2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFH complement factor H
CFI complement factor I
CLIC5 chloride intracellular channel 5
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL10 chemokine (C-X-C motif) ligand 10
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DMD dystrophin
DSE dermatan sulfate epimerase
DUSP1 dual specificity phosphatase 1
EPHB2 EPH receptor B2
ERAP2 endoplasmic reticulum aminopeptidase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FBN1 fibrillin 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FSCN1 fascin actin-bundling protein 1
FYB FYN binding protein
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GATA6 GATA binding protein 6
GSN gelsolin
HIST1H2AC histone cluster 1, H2ac
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
JAG1 jagged 1
JUP junction plakoglobin
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
LAMB1 laminin, beta 1
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LOX lysyl oxidase
LRRN3 leucine rich repeat neuronal 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMD monocyte to macrophage differentiation-associated
MVP major vault protein
MYB v-myb avian myeloblastosis viral oncogene homolog
NEFL neurofilament, light polypeptide
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFC platelet derived growth factor C
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
RBP4 retinol binding protein 4, plasma
RHOBTB3 Rho-related BTB domain containing 3
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
SSBP2 single-stranded DNA binding protein 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAB1 stabilin 1
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
BEX1 brain expressed, X-linked 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNF cyclin F
CCP110 centriolar coiled coil protein 110kDa
CXORF57 chromosome X open reading frame 57
CYB5A cytochrome b5 type A (microsomal)
DENND2D DENN/MADD domain containing 2D
GPM6B glycoprotein M6B
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KRT13 keratin 13, type I
NTS neurotensin
PFN2 profilin 2
TMEM176B transmembrane protein 176B
WASF1 WAS protein family, member 1
ZCCHC2 zinc finger, CCHC domain containing 2