BRD-K99545815_PF-562271_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K99545815_PF-562271_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACLY ATP citrate lyase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASRGL1 asparaginase like 1
CA2 carbonic anhydrase II
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
DDIT4 DNA-damage-inducible transcript 4
FASN fatty acid synthase
FASTKD5 FAST kinase domains 5
FYB FYN binding protein
GRB14 growth factor receptor-bound protein 14
GSN gelsolin
H1F0 H1 histone family, member 0
ITM2A integral membrane protein 2A
LPL lipoprotein lipase
MALL mal, T-cell differentiation protein-like
MAOB monoamine oxidase B
MLF1 myeloid leukemia factor 1
MMP9 matrix metallopeptidase 9
NFIL3 nuclear factor, interleukin 3 regulated
PRKCH protein kinase C, eta
PRSS8 protease, serine, 8
PSPH phosphoserine phosphatase
SCD5 stearoyl-CoA desaturase 5
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TCTN2 tectonic family member 2
TFPI2 tissue factor pathway inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARL4C ADP-ribosylation factor-like 4C
BMP4 bone morphogenetic protein 4
CCNF cyclin F
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHN1 chimerin 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNOT4 CCR4-NOT transcription complex, subunit 4
COL13A1 collagen, type XIII, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FZD7 frizzled class receptor 7
GRB10 growth factor receptor-bound protein 10
H2AFX H2A histone family, member X
HOXA10 homeobox A10
HSPA8 heat shock 70kDa protein 8
IER5 immediate early response 5
JADE2 jade family PHD finger 2
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
MID1IP1 MID1 interacting protein 1
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NCAM1 neural cell adhesion molecule 1
NOTCH2NL notch 2 N-terminal like
NUP62 nucleoporin 62kDa
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
RIN2 Ras and Rab interactor 2
RND3 Rho family GTPase 3
RPP38 ribonuclease P/MRP 38kDa subunit
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SRGN serglycin
SULF1 sulfatase 1
TACC2 transforming, acidic coiled-coil containing protein 2
WEE1 WEE1 G2 checkpoint kinase
ZNF160 zinc finger protein 160