BRD-K99545815_PF-562271_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K99545815_PF-562271_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADGRE5 adhesion G protein-coupled receptor E5
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
CCL19 chemokine (C-C motif) ligand 19
CSRP2 cysteine and glycine-rich protein 2
CTTN cortactin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
ELF1 E74-like factor 1 (ets domain transcription factor)
FOLR1 folate receptor 1 (adult)
FYB FYN binding protein
GPX2 glutathione peroxidase 2
GSN gelsolin
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6R interleukin 6 receptor
ITK IL2-inducible T-cell kinase
JAG1 jagged 1
KLF9 Kruppel-like factor 9
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP10 matrix metallopeptidase 10
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PRNP prion protein
PRUNE2 prune homolog 2 (Drosophila)
RUNX3 runt-related transcription factor 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
STAB1 stabilin 1
STAT4 signal transducer and activator of transcription 4
TGFBR3 transforming growth factor, beta receptor III
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAK2 trafficking protein, kinesin binding 2
VWF von Willebrand factor

decreased expression

Symbol Name
BEX1 brain expressed, X-linked 1
C1QTNF3 C1q and tumor necrosis factor related protein 3
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CDC20 cell division cycle 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLIC3 chloride intracellular channel 3
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
DCN decorin
FASN fatty acid synthase
GRB14 growth factor receptor-bound protein 14
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB3 high mobility group box 3
HP haptoglobin
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLK12 kallikrein-related peptidase 12
LUM lumican
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POSTN periostin, osteoblast specific factor
PSRC1 proline/serine-rich coiled-coil 1
RAD51C RAD51 paralog C
RRM2 ribonucleotide reductase M2
THBS1 thrombospondin 1
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican