BRD-K99545815_PF-562271_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K99545815_PF-562271_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR1C3 aldo-keto reductase family 1, member C3
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
C4BPA complement component 4 binding protein, alpha
C8ORF4 chromosome 8 open reading frame 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIB1 calcium and integrin binding 1 (calmyrin)
CLU clusterin
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DACH1 dachshund family transcription factor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPP4 dipeptidyl-peptidase 4
FLNB filamin B, beta
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
ITM2C integral membrane protein 2C
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LAPTM5 lysosomal protein transmembrane 5
MALL mal, T-cell differentiation protein-like
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MTUS1 microtubule associated tumor suppressor 1
MYOF myoferlin
NMT2 N-myristoyltransferase 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ORM1 orosomucoid 1
PCP4 Purkinje cell protein 4
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLAC8 placenta-specific 8
PON3 paraoxonase 3
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCH protein kinase C, eta
PSD3 pleckstrin and Sec7 domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPP1 secreted phosphoprotein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SQRDL sulfide quinone reductase-like (yeast)
SRGN serglycin
TSC22D1 TSC22 domain family, member 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRL2 adhesion G protein-coupled receptor L2
AK4 adenylate kinase 4
AMIGO2 adhesion molecule with Ig-like domain 2
CCL2 chemokine (C-C motif) ligand 2
CFLAR CASP8 and FADD-like apoptosis regulator
CHMP4A charged multivesicular body protein 4A
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CYB5A cytochrome b5 type A (microsomal)
DACT1 dishevelled-binding antagonist of beta-catenin 1
DLC1 DLC1 Rho GTPase activating protein
EGR1 early growth response 1
EGR2 early growth response 2
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
GAS1 growth arrest-specific 1
GBP1 guanylate binding protein 1, interferon-inducible
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB6 heat shock protein, alpha-crystallin-related, B6
ICAM1 intercellular adhesion molecule 1
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
KIAA0226L KIAA0226-like
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LMCD1 LIM and cysteine-rich domains 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MOK MOK protein kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOP56 NOP56 ribonucleoprotein
NREP neuronal regeneration related protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PYCR1 pyrroline-5-carboxylate reductase 1
RABGGTB Rab geranylgeranyltransferase, beta subunit
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
SRSF2 serine/arginine-rich splicing factor 2
STC2 stanniocalcin 2
TBX2 T-box 2
TFRC transferrin receptor
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TUBB6 tubulin, beta 6 class V
VCAN versican
VEGFA vascular endothelial growth factor A