BRD-K99252563_QL-XII-47_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

384 genes differentially expressed following the BRD-K99252563_QL-XII-47_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ACVR1B activin A receptor, type IB
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD10 ankyrin repeat domain 10
ANKRD28 ankyrin repeat domain 28
APOLD1 apolipoprotein L domain containing 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARFIP2 ADP-ribosylation factor interacting protein 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
ATF6 activating transcription factor 6
ATXN1 ataxin 1
AURKA aurora kinase A
AURKB aurora kinase B
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BANP BTG3 associated nuclear protein
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD2 bromodomain containing 2
CCDC53 coiled-coil domain containing 53
CCNG2 cyclin G2
CD163 CD163 molecule
CDC14B cell division cycle 14B
CDC34 cell division cycle 34
CDK12 cyclin-dependent kinase 12
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP350 centrosomal protein 350kDa
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CLK4 CDC-like kinase 4
CRISP3 cysteine-rich secretory protein 3
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DIAPH2 diaphanous-related formin 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFNA1 ephrin-A1
ELF1 E74-like factor 1 (ets domain transcription factor)
ELL2 elongation factor, RNA polymerase II, 2
FAM134B family with sequence similarity 134, member B
FAM193A family with sequence similarity 193, member A
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FLOT1 flotillin 1
FOXO3 forkhead box O3
FZD5 frizzled class receptor 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GGNBP2 gametogenetin binding protein 2
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JMJD6 jumonji domain containing 6
KAT6B K(lysine) acetyltransferase 6B
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KIAA0907 KIAA0907
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRAS Kirsten rat sarcoma viral oncogene homolog
KRCC1 lysine-rich coiled-coil 1
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
MAD2L1BP MAD2L1 binding protein
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MID1 midline 1
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NAMPT nicotinamide phosphoribosyltransferase
NAV2 neuron navigator 2
NBPF10 neuroblastoma breakpoint family, member 10
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NOTCH2NL notch 2 N-terminal like
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OSBPL11 oxysterol binding protein-like 11
OSER1 oxidative stress responsive serine-rich 1
PCGF1 polycomb group ring finger 1
PDGFC platelet derived growth factor C
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PER2 period circadian clock 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHF3 PHD finger protein 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB4 phospholipase C, beta 4
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLS1 plastin 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSPC1 paraspeckle component 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PYGL phosphorylase, glycogen, liver
QPCT glutaminyl-peptide cyclotransferase
RAB13 RAB13, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RALBP1 ralA binding protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOBTB3 Rho-related BTB domain containing 3
RIOK2 RIO kinase 2
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RLF rearranged L-myc fusion
RNF24 ring finger protein 24
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS27L ribosomal protein S27-like
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAP30 Sin3A-associated protein, 30kDa
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEC24B SEC24 family member B
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERTAD2 SERTA domain containing 2
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMIM7 small integral membrane protein 7
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STC2 stanniocalcin 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYBU syntabulin (syntaxin-interacting)
TBC1D15 TBC1 domain family, member 15
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
UBAP1 ubiquitin associated protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBXN7 UBX domain protein 7
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
YTHDC1 YTH domain containing 1
YY1AP1 YY1 associated protein 1
ZBTB16 zinc finger and BTB domain containing 16
ZCCHC6 zinc finger, CCHC domain containing 6
ZMYM2 zinc finger, MYM-type 2
ZNF24 zinc finger protein 24
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACPP acid phosphatase, prostate
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADA adenosine deaminase
ADGRG1 adhesion G protein-coupled receptor G1
ADGRL2 adhesion G protein-coupled receptor L2
AEBP1 AE binding protein 1
AHCY adenosylhomocysteinase
AK2 adenylate kinase 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASPH aspartate beta-hydroxylase
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BECN1 beclin 1, autophagy related
BLCAP bladder cancer associated protein
BST2 bone marrow stromal cell antigen 2
C1ORF106 chromosome 1 open reading frame 106
C1ORF116 chromosome 1 open reading frame 116
C3 complement component 3
C7 complement component 7
CALD1 caldesmon 1
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CD47 CD47 molecule
CFH complement factor H
CHGB chromogranin B
CLNS1A chloride channel, nucleotide-sensitive, 1A
CNN1 calponin 1, basic, smooth muscle
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CRLF1 cytokine receptor-like factor 1
CSTA cystatin A (stefin A)
CTSH cathepsin H
DCN decorin
DERL1 derlin 1
DES desmin
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLAT dihydrolipoamide S-acetyltransferase
DLD dihydrolipoamide dehydrogenase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPYSL2 dihydropyrimidinase-like 2
ELOVL6 ELOVL fatty acid elongase 6
ENOSF1 enolase superfamily member 1
ERMP1 endoplasmic reticulum metallopeptidase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FASN fatty acid synthase
FCHSD2 FCH and double SH3 domains 2
FERMT1 fermitin family member 1
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FKBP1A FK506 binding protein 1A, 12kDa
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GDE1 glycerophosphodiester phosphodiesterase 1
GLUD1 glutamate dehydrogenase 1
GLUD2 glutamate dehydrogenase 2
GOLGA8B golgin A8 family, member B
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGHM immunoglobulin heavy constant mu
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INSIG1 insulin induced gene 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JCHAIN joining chain of multimeric IgA and IgM
KLK2 kallikrein-related peptidase 2
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT81 keratin 81, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
LITAF lipopolysaccharide-induced TNF factor
LPCAT4 lysophosphatidylcholine acyltransferase 4
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LYPLA1 lysophospholipase I
MAGEH1 melanoma antigen family H1
MALL mal, T-cell differentiation protein-like
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MOCOS molybdenum cofactor sulfurase
MXRA7 matrix-remodelling associated 7
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
MYH11 myosin, heavy chain 11, smooth muscle
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPD3 non-SMC condensin II complex, subunit D3
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NUP210 nucleoporin 210kDa
OAT ornithine aminotransferase
P4HB prolyl 4-hydroxylase, beta polypeptide
PARP1 poly (ADP-ribose) polymerase 1
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PLBD1 phospholipase B domain containing 1
PLXNB1 plexin B1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRDX1 peroxiredoxin 1
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSAT1 phosphoserine aminotransferase 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPA1 replication protein A1, 70kDa
RPN2 ribophorin II
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPW1 selenoprotein W, 1
SERBP1 SERPINE1 mRNA binding protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLPI secretory leukocyte peptidase inhibitor
SPON2 spondin 2, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
SRSF5 serine/arginine-rich splicing factor 5
SRSF7 serine/arginine-rich splicing factor 7
SYPL1 synaptophysin-like 1
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TARP TCR gamma alternate reading frame protein
TFDP1 transcription factor Dp-1
TGM2 transglutaminase 2
TM9SF2 transmembrane 9 superfamily member 2
TMEM230 transmembrane protein 230
TMPRSS2 transmembrane protease, serine 2
TMSB15A thymosin beta 15a
TSPAN3 tetraspanin 3
TSPYL1 TSPY-like 1
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
UBE3C ubiquitin protein ligase E3C
UQCRC2 ubiquinol-cytochrome c reductase core protein II
URI1 URI1, prefoldin-like chaperone
WDR61 WD repeat domain 61
WFDC1 WAP four-disulfide core domain 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZMIZ1 zinc finger, MIZ-type containing 1