BRD-K99252563_QL-XII-47_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K99252563_QL-XII-47_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANPEP alanyl (membrane) aminopeptidase
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CA12 carbonic anhydrase XII
CCNL1 cyclin L1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHI3L2 chitinase 3-like 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN3 claudin 3
CPE carboxypeptidase E
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
EGFR epidermal growth factor receptor
EGR1 early growth response 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCLC glutamate-cysteine ligase, catalytic subunit
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIF14 kinesin family member 14
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP7 matrix metallopeptidase 7
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PAN2 PAN2 poly(A) specific ribonuclease subunit
PER1 period circadian clock 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLXDC1 plexin domain containing 1
PSD3 pleckstrin and Sec7 domain containing 3
PSPC1 paraspeckle component 1
PTN pleiotrophin
RAP1GAP RAP1 GTPase activating protein
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SOX4 SRY (sex determining region Y)-box 4
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM2 transmembrane protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
VCAN versican
ZFP36L1 ZFP36 ring finger protein-like 1
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AIM2 absent in melanoma 2
B3GNT1
C2CD2 C2 calcium-dependent domain containing 2
C6ORF62 chromosome 6 open reading frame 62
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM171A1 family with sequence similarity 171, member A1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB7 homeobox B7
IGL immunoglobulin lambda locus
LAPTM4B lysosomal protein transmembrane 4 beta
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCAM melanoma cell adhesion molecule
MEIS1 Meis homeobox 1
MYLK myosin light chain kinase
NR2F6 nuclear receptor subfamily 2, group F, member 6
NTS neurotensin
ODC1 ornithine decarboxylase 1
PODXL podocalyxin-like
PRDX2 peroxiredoxin 2
RALGDS ral guanine nucleotide dissociation stimulator
RRAGD Ras-related GTP binding D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SERINC5 serine incorporator 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM243 transmembrane protein 243, mitochondrial
TSPAN3 tetraspanin 3