BRD-K99252563_QL-XII-47_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

272 genes differentially expressed following the BRD-K99252563_QL-XII-47_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADRB2 adrenoceptor beta 2, surface
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANKRD10 ankyrin repeat domain 10
ANKRD12 ankyrin repeat domain 12
ANXA1 annexin A1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARL8B ADP-ribosylation factor-like 8B
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATG101 autophagy related 101
BIRC2 baculoviral IAP repeat containing 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC93 coiled-coil domain containing 93
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CFP complement factor properdin
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CRABP1 cellular retinoic acid binding protein 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYB561 cytochrome b561
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK3 death-associated protein kinase 3
DDIT3 DNA-damage-inducible transcript 3
DLX2 distal-less homeobox 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EHD1 EH-domain containing 1
EMC3 ER membrane protein complex subunit 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGF13 fibroblast growth factor 13
FNTA farnesyltransferase, CAAX box, alpha
FOSL1 FOS-like antigen 1
FZD5 frizzled class receptor 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GOLGA8A golgin A8 family, member A
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL2RG interleukin 2 receptor, gamma
IL6R interleukin 6 receptor
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KCMF1 potassium channel modulatory factor 1
KDM5B lysine (K)-specific demethylase 5B
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MED13 mediator complex subunit 13
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NBPF10 neuroblastoma breakpoint family, member 10
NCF2 neutrophil cytosolic factor 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLCB4 phospholipase C, beta 4
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSEN1 presenilin 1
PSPC1 paraspeckle component 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RCOR3 REST corepressor 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RNMT RNA (guanine-7-) methyltransferase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERTAD2 SERTA domain containing 2
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIK3 SIK family kinase 3
SIRT1 sirtuin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNX11 sorting nexin 11
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TATDN2 TatD DNase domain containing 2
TFE3 transcription factor binding to IGHM enhancer 3
TGIF1 TGFB-induced factor homeobox 1
TICAM1 toll-like receptor adaptor molecule 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TTC17 tetratricopeptide repeat domain 17
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBAP1 ubiquitin associated protein 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
UPP1 uridine phosphorylase 1
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
XIST X inactive specific transcript (non-protein coding)
YTHDC1 YTH domain containing 1
ZBTB43 zinc finger and BTB domain containing 43
ZC3H11A zinc finger CCCH-type containing 11A
ZCCHC6 zinc finger, CCHC domain containing 6
ZNF451 zinc finger protein 451
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADGRG6 adhesion G protein-coupled receptor G6
AKT1 v-akt murine thymoma viral oncogene homolog 1
APMAP adipocyte plasma membrane associated protein
AUTS2 autism susceptibility candidate 2
B3GNT1
BACE2 beta-site APP-cleaving enzyme 2
BCHE butyrylcholinesterase
CA12 carbonic anhydrase XII
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCNG1 cyclin G1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CETN2 centrin, EF-hand protein, 2
CFH complement factor H
CFI complement factor I
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A3 collagen, type VI, alpha 3
CRTAP cartilage associated protein
CSTA cystatin A (stefin A)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DPYSL2 dihydropyrimidinase-like 2
DUT deoxyuridine triphosphatase
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EVL Enah/Vasp-like
FAM3C family with sequence similarity 3, member C
FASN fatty acid synthase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HMGA2 high mobility group AT-hook 2
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
INSIG1 insulin induced gene 1
ISYNA1 inositol-3-phosphate synthase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KAZN kazrin, periplakin interacting protein
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MAGED1 melanoma antigen family D1
MANSC1 MANSC domain containing 1
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MXRA5 matrix-remodelling associated 5
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
NCAPG2 non-SMC condensin II complex, subunit G2
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NES nestin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5DC2 5'-nucleotidase domain containing 2
OBSL1 obscurin-like 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PAM peptidylglycine alpha-amidating monooxygenase
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PEBP1 phosphatidylethanolamine binding protein 1
PHGDH phosphoglycerate dehydrogenase
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS23 protease, serine, 23
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
RAB11A RAB11A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A4RG SLC2A4 regulator
SNX10 sorting nexin 10
SPARCL1 SPARC-like 1 (hevin)
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK39 serine threonine kinase 39
STMN1 stathmin 1
SUMO3 small ubiquitin-like modifier 3
TACC1 transforming, acidic coiled-coil containing protein 1
TBC1D16 TBC1 domain family, member 16
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS2 thrombospondin 2
TIMELESS timeless circadian clock
TMEM2 transmembrane protein 2
TMEM243 transmembrane protein 243, mitochondrial
TMEM50B transmembrane protein 50B
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TYMS thymidylate synthetase