BRD-K98676510_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-pyridin-2-ylthiophene-2-sulfonamide_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K98676510_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-pyridin-2-ylthiophene-2-sulfonamide_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ALDOC aldolase C, fructose-bisphosphate
ANOS1 anosmin 1
ARHGAP29 Rho GTPase activating protein 29
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL20 chemokine (C-C motif) ligand 20
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEMIP cell migration inducing protein, hyaluronan binding
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CTH cystathionine gamma-lyase
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYTL1 cytokine-like 1
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FABP7 fatty acid binding protein 7, brain
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
GPM6A glycoprotein M6A
GSN gelsolin
HECA headcase homolog (Drosophila)
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGHMBP2 immunoglobulin mu binding protein 2
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KIAA1033 KIAA1033
LAPTM5 lysosomal protein transmembrane 5
MCOLN1 mucolipin 1
MFSD10 major facilitator superfamily domain containing 10
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
MSN moesin
NNMT nicotinamide N-methyltransferase
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP3 nuclear receptor interacting protein 3
OPN3 opsin 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD9A RAD9 homolog A (S. pombe)
RNASET2 ribonuclease T2
RNF167 ring finger protein 167
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
SST somatostatin
STOM stomatin
STX1A syntaxin 1A (brain)
TIMP3 TIMP metallopeptidase inhibitor 3
TRAK2 trafficking protein, kinesin binding 2
TRIM36 tripartite motif containing 36
TXNDC9 thioredoxin domain containing 9
TXNIP thioredoxin interacting protein
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VIM vimentin

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADM adrenomedullin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARID1A AT rich interactive domain 1A (SWI-like)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CD34 CD34 molecule
CKAP4 cytoskeleton-associated protein 4
COG7 component of oligomeric golgi complex 7
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
EIF5 eukaryotic translation initiation factor 5
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
F12 coagulation factor XII (Hageman factor)
FAM69A family with sequence similarity 69, member A
FHL1 four and a half LIM domains 1
FXYD3 FXYD domain containing ion transport regulator 3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGFBP6 insulin-like growth factor binding protein 6
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MTMR1 myotubularin related protein 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NRIP1 nuclear receptor interacting protein 1
PLBD1 phospholipase B domain containing 1
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
REPIN1 replication initiator 1
RND3 Rho family GTPase 3
S100A12 S100 calcium binding protein A12
SENP6 SUMO1/sentrin specific peptidase 6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SMAGP small cell adhesion glycoprotein
SPON2 spondin 2, extracellular matrix protein
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TFF1 trefoil factor 1
TP63 tumor protein p63
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
USP22 ubiquitin specific peptidase 22
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF512B zinc finger protein 512B