BRD-K98676510_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-pyridin-2-ylthiophene-2-sulfonamide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

237 genes differentially expressed following the BRD-K98676510_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-pyridin-2-ylthiophene-2-sulfonamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAD8 acyl-CoA dehydrogenase family, member 8
ACOT7 acyl-CoA thioesterase 7
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ASMTL acetylserotonin O-methyltransferase-like
BACE2 beta-site APP-cleaving enzyme 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
BZW2 basic leucine zipper and W2 domains 2
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD4 CD4 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN5 claudin 5
CORO1A coronin, actin binding protein, 1A
CPD carboxypeptidase D
CRABP1 cellular retinoic acid binding protein 1
CTH cystathionine gamma-lyase
CTSA cathepsin A
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPAS1 endothelial PAS domain protein 1
ESYT1 extended synaptotagmin-like protein 1
FAM117A family with sequence similarity 117, member A
FBLN5 fibulin 5
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GLS glutaminase
GMCL1 germ cell-less, spermatogenesis associated 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPX3 glutathione peroxidase 3
GSDMB gasdermin B
HAL histidine ammonia-lyase
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HSPA1A heat shock 70kDa protein 1A
ICAM1 intercellular adhesion molecule 1
IGFBP5 insulin-like growth factor binding protein 5
INSR insulin receptor
IRF7 interferon regulatory factor 7
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
L1CAM L1 cell adhesion molecule
LIMA1 LIM domain and actin binding 1
LTA4H leukotriene A4 hydrolase
MACF1 microtubule-actin crosslinking factor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAPT microtubule-associated protein tau
MLF1 myeloid leukemia factor 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NSG1 neuron specific gene family member 1
OLFM1 olfactomedin 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
POLB polymerase (DNA directed), beta
PRSS3 protease, serine, 3
PSPH phosphoserine phosphatase
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PXDN peroxidasin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS10 regulator of G-protein signaling 10
RIMS3 regulating synaptic membrane exocytosis 3
RRAGC Ras-related GTP binding C
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A1 solute carrier family 38, member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SST somatostatin
STX7 syntaxin 7
STXBP1 syntaxin binding protein 1
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNS1 tensin 1
TPST2 tyrosylprotein sulfotransferase 2
TSPAN7 tetraspanin 7
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAM1 vascular cell adhesion molecule 1
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF281 zinc finger protein 281

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKAP8 A kinase (PRKA) anchor protein 8
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
APOL1 apolipoprotein L, 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
BCLAF1 BCL2-associated transcription factor 1
C7ORF49 chromosome 7 open reading frame 49
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CKAP4 cytoskeleton-associated protein 4
COL18A1 collagen, type XVIII, alpha 1
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CXCL8 chemokine (C-X-C motif) ligand 8
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUOX2 dual oxidase 2
EDN1 endothelin 1
EFS embryonal Fyn-associated substrate
EIF4A1 eukaryotic translation initiation factor 4A1
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPN2 epsin 2
EREG epiregulin
FAM57A family with sequence similarity 57, member A
FBN2 fibrillin 2
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GCLM glutamate-cysteine ligase, modifier subunit
GEMIN4 gem (nuclear organelle) associated protein 4
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
HDDC2 HD domain containing 2
HOPX HOP homeobox
HOXA10 homeobox A10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP6 insulin-like growth factor binding protein 6
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KRT7 keratin 7, type II
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LCN2 lipocalin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPK6 mitogen-activated protein kinase 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MSL1 male-specific lethal 1 homolog (Drosophila)
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYOF myoferlin
NAV3 neuron navigator 3
NBN nibrin
NFE2L2 nuclear factor, erythroid 2-like 2
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARVB parvin, beta
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
QKI QKI, KH domain containing, RNA binding
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SALL1 spalt-like transcription factor 1
SENP6 SUMO1/sentrin specific peptidase 6
SFRP1 secreted frizzled-related protein 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SOX17 SRY (sex determining region Y)-box 17
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF1 trefoil factor 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCK2 uridine-cytidine kinase 2
UPK1B uroplakin 1B
VGLL4 vestigial-like family member 4
WNT5A wingless-type MMTV integration site family, member 5A