BRD-K98676510_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-pyridin-2-ylthiophene-2-sulfonamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K98676510_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-pyridin-2-ylthiophene-2-sulfonamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
CYB5R1 cytochrome b5 reductase 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSTN destrin (actin depolymerizing factor)
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HEBP1 heme binding protein 1
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
MGP matrix Gla protein
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MPC2 mitochondrial pyruvate carrier 2
MSRB1 methionine sulfoxide reductase B1
MT1F metallothionein 1F
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
NIT1 nitrilase 1
NME7 NME/NM23 family member 7
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G16 phospholipase A2, group XVI
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTN pleiotrophin
RABAC1 Rab acceptor 1 (prenylated)
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN3 reticulon 3
S100A11 S100 calcium binding protein A11
S100A8 S100 calcium binding protein A8
SEPT6 septin 6
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM45A transmembrane protein 45A
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCL vinculin
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BHLHE41 basic helix-loop-helix family, member e41
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CTSG cathepsin G
DCTD dCMP deaminase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EREG epiregulin
FXYD3 FXYD domain containing ion transport regulator 3
GSAP gamma-secretase activating protein
HMGA2 high mobility group AT-hook 2
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM2 minichromosome maintenance complex component 2
MEIS2 Meis homeobox 2
MICALL1 MICAL-like 1
MOK MOK protein kinase
MPO myeloperoxidase
MRPS2 mitochondrial ribosomal protein S2
OBSL1 obscurin-like 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGCC regulator of cell cycle
RTP4 receptor (chemosensory) transporter protein 4
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS1 thrombospondin 1
TRIB3 tribbles pseudokinase 3
XIST X inactive specific transcript (non-protein coding)
ZHX2 zinc fingers and homeoboxes 2