BRD-K97764662_PD-173074_HS578T_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K97764662_PD-173074_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACAT2 acetyl-CoA acetyltransferase 2
ADA adenosine deaminase
ALDOB aldolase B, fructose-bisphosphate
ANXA4 annexin A4
ASPN asporin
ASS1 argininosuccinate synthase 1
BHMT betaine--homocysteine S-methyltransferase
BTG2 BTG family, member 2
CBS cystathionine-beta-synthase
CCNG1 cyclin G1
CD163 CD163 molecule
CELF2 CUGBP, Elav-like family member 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL11A1 collagen, type XI, alpha 1
CSF1R colony stimulating factor 1 receptor
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DMBT1 deleted in malignant brain tumors 1
DMTF1 cyclin D binding myb-like transcription factor 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FBLN1 fibulin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
GLS glutaminase
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPNMB glycoprotein (transmembrane) nmb
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPD 4-hydroxyphenylpyruvate dioxygenase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MFAP5 microfibrillar associated protein 5
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MX1 MX dynamin-like GTPase 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPB surfactant protein B
SH3YL1 SH3 and SYLF domain containing 1
SLC38A1 solute carrier family 38, member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
STK26 serine/threonine protein kinase 26
TDO2 tryptophan 2,3-dioxygenase
TMEM97 transmembrane protein 97
TNS3 tensin 3
TSC22D3 TSC22 domain family, member 3
TYROBP TYRO protein tyrosine kinase binding protein
WARS tryptophanyl-tRNA synthetase
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGAP29 Rho GTPase activating protein 29
ASPH aspartate beta-hydroxylase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CLGN calmegin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HMGA1 high mobility group AT-hook 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
JUN jun proto-oncogene
LIG1 ligase I, DNA, ATP-dependent
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
NOP56 NOP56 ribonucleoprotein
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLIN1 perilipin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RIN2 Ras and Rab interactor 2
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TIMELESS timeless circadian clock
TIMP4 TIMP metallopeptidase inhibitor 4
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
UGDH UDP-glucose 6-dehydrogenase
UNG uracil-DNA glycosylase
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WNT5A wingless-type MMTV integration site family, member 5A
ZWINT ZW10 interacting kinetochore protein