BRD-K97534490_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K97534490_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ATF3 activating transcription factor 3
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CRCT1 cysteine-rich C-terminal 1
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
EGR1 early growth response 1
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HES1 hes family bHLH transcription factor 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT16 keratin 16, type I
KRT23 keratin 23, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MBNL2 muscleblind-like splicing regulator 2
MT1E metallothionein 1E
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RBP1 retinol binding protein 1, cellular
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SST somatostatin
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
BAMBI BMP and activin membrane-bound inhibitor
BHLHE41 basic helix-loop-helix family, member e41
CCND2 cyclin D2
CD99 CD99 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
DACH1 dachshund family transcription factor 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FTH1 ferritin, heavy polypeptide 1
GATA3 GATA binding protein 3
GSTM3 glutathione S-transferase mu 3 (brain)
HEG1 heart development protein with EGF-like domains 1
HMOX1 heme oxygenase 1
IGFBP7 insulin-like growth factor binding protein 7
IL17RB interleukin 17 receptor B
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LXN latexin
MARC1 mitochondrial amidoxime reducing component 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
NID2 nidogen 2 (osteonidogen)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PDIA3 protein disulfide isomerase family A, member 3
PDZD2 PDZ domain containing 2
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PODXL podocalyxin-like
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RXRA retinoid X receptor, alpha
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TFF1 trefoil factor 1
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
WWOX WW domain containing oxidoreductase