BRD-K97399794_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K97399794_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COLEC12 collectin sub-family member 12
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSK cathepsin K
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP3 dual specificity phosphatase 3
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FST follistatin
GREM1 gremlin 1, DAN family BMP antagonist
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
INHBA inhibin, beta A
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KANK1 KN motif and ankyrin repeat domains 1
KLHL9 kelch-like family member 9
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KYNU kynureninase
LDB3 LIM domain binding 3
LDOC1 leucine zipper, down-regulated in cancer 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MLPH melanophilin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MYOF myoferlin
NCAM1 neural cell adhesion molecule 1
NNMT nicotinamide N-methyltransferase
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
PDLIM3 PDZ and LIM domain 3
PRNP prion protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RSL1D1 ribosomal L1 domain containing 1
RSRP1 arginine/serine-rich protein 1
SCG5 secretogranin V
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQRDL sulfide quinone reductase-like (yeast)
SRGN serglycin
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULF1 sulfatase 1
SYNM synemin, intermediate filament protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TRPS1 trichorhinophalangeal syndrome I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
C2CD5 C2 calcium-dependent domain containing 5
C7 complement component 7
CCNA2 cyclin A2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CTSH cathepsin H
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FXYD2 FXYD domain containing ion transport regulator 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GSTA1 glutathione S-transferase alpha 1
HDAC2 histone deacetylase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
MSH6 mutS homolog 6
NCK1 NCK adaptor protein 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
ZMYM2 zinc finger, MYM-type 2