BRD-K97274161_N-{2-[benzyl(isopropyl)amino]ethyl}-4-({[(4-methylphenyl)sulfonyl]amino}methyl)benzamide_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K97274161_N-{2-[benzyl(isopropyl)amino]ethyl}-4-({[(4-methylphenyl)sulfonyl]amino}methyl)benzamide_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ALDOC aldolase C, fructose-bisphosphate
ANXA4 annexin A4
ASMTL acetylserotonin O-methyltransferase-like
AUTS2 autism susceptibility candidate 2
BHLHE40 basic helix-loop-helix family, member e40
CCND2 cyclin D2
CETN2 centrin, EF-hand protein, 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
EBP emopamil binding protein (sterol isomerase)
EFNB2 ephrin-B2
ELOVL6 ELOVL fatty acid elongase 6
EPS8 epidermal growth factor receptor pathway substrate 8
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGFR3 fibroblast growth factor receptor 3
G6PD glucose-6-phosphate dehydrogenase
GATA3 GATA binding protein 3
GCA grancalcin, EF-hand calcium binding protein
GLUL glutamate-ammonia ligase
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
KDM5D lysine (K)-specific demethylase 5D
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAN1A1 mannosidase, alpha, class 1A, member 1
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PCCA propionyl CoA carboxylase, alpha polypeptide
PCP4 Purkinje cell protein 4
PENK proenkephalin
PFKL phosphofructokinase, liver
PPAP2B phosphatidic acid phosphatase type 2B
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
QPCT glutaminyl-peptide cyclotransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPAG4 sperm associated antigen 4
SQLE squalene epoxidase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM97 transmembrane protein 97
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor

decreased expression

Symbol Name
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
ANXA1 annexin A1
ARHGAP29 Rho GTPase activating protein 29
BID BH3 interacting domain death agonist
C8ORF4 chromosome 8 open reading frame 4
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EMP1 epithelial membrane protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FSCN1 fascin actin-bundling protein 1
GOLM1 golgi membrane protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HSPB8 heat shock 22kDa protein 8
KRT23 keratin 23, type I
LAMP3 lysosomal-associated membrane protein 3
MAB21L2 mab-21-like 2 (C. elegans)
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1E metallothionein 1E
MT2A metallothionein 2A
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDLIM5 PDZ and LIM domain 5
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TM4SF1 transmembrane 4 L six family member 1
TPD52 tumor protein D52
TRAM1 translocation associated membrane protein 1
XIST X inactive specific transcript (non-protein coding)
ZEB1 zinc finger E-box binding homeobox 1