BRD-K97274161_N-{2-[benzyl(isopropyl)amino]ethyl}-4-({[(4-methylphenyl)sulfonyl]amino}methyl)benzamide_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K97274161_N-{2-[benzyl(isopropyl)amino]ethyl}-4-({[(4-methylphenyl)sulfonyl]amino}methyl)benzamide_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACAT2 acetyl-CoA acetyltransferase 2
ADD3 adducin 3 (gamma)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ASS1 argininosuccinate synthase 1
BZW2 basic leucine zipper and W2 domains 2
CFB complement factor B
CLGN calmegin
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUOX2 dual oxidase 2
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP2 guanylate binding protein 2, interferon-inducible
GPX2 glutathione peroxidase 2
H1F0 H1 histone family, member 0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KLF5 Kruppel-like factor 5 (intestinal)
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
OLFM4 olfactomedin 4
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCP4 Purkinje cell protein 4
PHYH phytanoyl-CoA 2-hydroxylase
PRDX2 peroxiredoxin 2
PRUNE2 prune homolog 2 (Drosophila)
RAP1GAP RAP1 GTPase activating protein
RGS5 regulator of G-protein signaling 5
S100P S100 calcium binding protein P
SATB1 SATB homeobox 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC22A18 solute carrier family 22, member 18
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK4 serine peptidase inhibitor, Kazal type 4
SPP1 secreted phosphoprotein 1
TECR trans-2,3-enoyl-CoA reductase
THY1 Thy-1 cell surface antigen
TST thiosulfate sulfurtransferase (rhodanese)
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
COL3A1 collagen, type III, alpha 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FASTKD5 FAST kinase domains 5
HIST1H1C histone cluster 1, H1c
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
KRT7 keratin 7, type II
LHX2 LIM homeobox 2
LIMCH1 LIM and calponin homology domains 1
LUM lumican
MACF1 microtubule-actin crosslinking factor 1
MX1 MX dynamin-like GTPase 1
ORC1 origin recognition complex, subunit 1
PDLIM3 PDZ and LIM domain 3
POSTN periostin, osteoblast specific factor
RRM2 ribonucleotide reductase M2
SLC43A3 solute carrier family 43, member 3
TUBB6 tubulin, beta 6 class V