BRD-K97181089_3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide KAJ-25_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K97181089_3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide KAJ-25_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACE2 angiotensin I converting enzyme 2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKAP13 A kinase (PRKA) anchor protein 13
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
AXL AXL receptor tyrosine kinase
BAG2 BCL2-associated athanogene 2
BBX bobby sox homolog (Drosophila)
C1S complement component 1, s subcomponent
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CHGB chromogranin B
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL4A5 collagen, type IV, alpha 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCLRE1C DNA cross-link repair 1C
DKK1 dickkopf WNT signaling pathway inhibitor 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELF5 E74-like factor 5 (ets domain transcription factor)
EMX2 empty spiracles homeobox 2
FOLR1 folate receptor 1 (adult)
GATA3 GATA binding protein 3
GPM6B glycoprotein M6B
GSTA1 glutathione S-transferase alpha 1
HIST1H2BG histone cluster 1, H2bg
IDE insulin-degrading enzyme
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IGHMBP2 immunoglobulin mu binding protein 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLHL9 kelch-like family member 9
LAMP3 lysosomal-associated membrane protein 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMCD1 LIM and cysteine-rich domains 1
METTL7A methyltransferase like 7A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYL2 myosin, light chain 2, regulatory, cardiac, slow
N4BP2L2 NEDD4 binding protein 2-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
PALMD palmdelphin
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEG3 paternally expressed 3
PGC progastricsin (pepsinogen C)
PHACTR2 phosphatase and actin regulator 2
PPAP2A phosphatidic acid phosphatase type 2A
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RFTN1 raftlin, lipid raft linker 1
RPS11 ribosomal protein S11
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SIK1 salt-inducible kinase 1
SOCS2 suppressor of cytokine signaling 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAR steroidogenic acute regulatory protein
SVIL supervillin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TNNC1 troponin C type 1 (slow)
TRIM22 tripartite motif containing 22
TRIM38 tripartite motif containing 38
TUG1 taurine up-regulated 1 (non-protein coding)
UPK1B uroplakin 1B
WIF1 WNT inhibitory factor 1
ZBTB16 zinc finger and BTB domain containing 16
ZBTB20 zinc finger and BTB domain containing 20
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ANXA4 annexin A4
ASMTL acetylserotonin O-methyltransferase-like
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BZW1 basic leucine zipper and W2 domains 1
CA2 carbonic anhydrase II
CANT1 calcium activated nucleotidase 1
CCDC109B coiled-coil domain containing 109B
CDC42 cell division cycle 42
CHMP4A charged multivesicular body protein 4A
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CPNE1 copine I
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DAD1 defender against cell death 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP6 dual specificity phosphatase 6
DYNLRB1 dynein, light chain, roadblock-type 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ENOPH1 enolase-phosphatase 1
FDPS farnesyl diphosphate synthase
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GORASP2 golgi reassembly stacking protein 2, 55kDa
GSS glutathione synthetase
HAT1 histone acetyltransferase 1
HIRA histone cell cycle regulator
HOXB7 homeobox B7
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
LEF1 lymphoid enhancer-binding factor 1
LITAF lipopolysaccharide-induced TNF factor
MET MET proto-oncogene, receptor tyrosine kinase
MRPS30 mitochondrial ribosomal protein S30
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NPTX2 neuronal pentraxin II
NRIP1 nuclear receptor interacting protein 1
NUSAP1 nucleolar and spindle associated protein 1
PCCB propionyl CoA carboxylase, beta polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PPT1 palmitoyl-protein thioesterase 1
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PTTG1 pituitary tumor-transforming 1
RHOC ras homolog family member C
RND3 Rho family GTPase 3
RNH1 ribonuclease/angiogenin inhibitor 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SCAND1 SCAN domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC35F2 solute carrier family 35, member F2
SNX10 sorting nexin 10
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRED2 sprouty-related, EVH1 domain containing 2
TLE4 transducin-like enhancer of split 4
TLK2 tousled-like kinase 2
TMEM176B transmembrane protein 176B
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPBG trophoblast glycoprotein
VCAN versican