BRD-K96271548_COUMARINIC ACID METHYL ETHER_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K96271548_COUMARINIC ACID METHYL ETHER_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ADAM10 ADAM metallopeptidase domain 10
ADGRL2 adhesion G protein-coupled receptor L2
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP11B ATPase, class VI, type 11B
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAM basal cell adhesion molecule (Lutheran blood group)
C10ORF10 chromosome 10 open reading frame 10
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CRABP2 cellular retinoic acid binding protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5A cytochrome b5 type A (microsomal)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK5 docking protein 5
EDN1 endothelin 1
EMP2 epithelial membrane protein 2
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FGG fibrinogen gamma chain
FLOT1 flotillin 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM2 intercellular adhesion molecule 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
JCHAIN joining chain of multimeric IgA and IgM
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDR kinase insert domain receptor
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS2 Meis homeobox 2
MMP7 matrix metallopeptidase 7
MUC16 mucin 16, cell surface associated
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRP1 neuropilin 1
OLFM4 olfactomedin 4
PAPD7 PAP associated domain containing 7
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAC8 placenta-specific 8
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SRGN serglycin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SUSD4 sushi domain containing 4
TBX2 T-box 2
TMEM30B transmembrane protein 30B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN12 tetraspanin 12
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
COL5A2 collagen, type V, alpha 2
CPVL carboxypeptidase, vitellogenic-like
CST3 cystatin C
F13A1 coagulation factor XIII, A1 polypeptide
FA2H fatty acid 2-hydroxylase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GOLGA8A golgin A8 family, member A
GSN gelsolin
H2AFX H2A histone family, member X
HOXC6 homeobox C6
KIAA0101 KIAA0101
LOXL1 lysyl oxidase-like 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
NFIB nuclear factor I/B
NOP56 NOP56 ribonucleoprotein
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCDH9 protocadherin 9
PCNA proliferating cell nuclear antigen
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEBP1 phosphatidylethanolamine binding protein 1
PLCB4 phospholipase C, beta 4
PRKCZ protein kinase C, zeta
PRSS3 protease, serine, 3
RCAN1 regulator of calcineurin 1
RPL37A ribosomal protein L37a
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SRSF6 serine/arginine-rich splicing factor 6
STAT1 signal transducer and activator of transcription 1, 91kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase